ML335 (Synonyms: CID23723457, CYM 51010) |
Catalog No.GC45675 |
An activator of K2P2.1/TREK1 and K2P10.1/TREK2
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Cas No.: 825658-06-8
Sample solution is provided at 25 µL, 10mM.
ML335 is an activator of the two-pore domain potassium channels K2P2.1/TREK1 and K2P10.1/TREK2 (EC50s = 14.3 and 5.2 μM, respectively, in Xenopus oocytes).1 It is selective for K2P2.1/TREK1 and K2P10.1/TREK2 channels over K2P4.1/TRAAK channels. ML335 activates K2P2.1/TREK1 by binding to the C-type gate, which is the active site of TREK channels.
|1. Lolicato, M., Arrigoni, C., Mori, T., et al. K2P2.1(TREK-1): Activator complexes reveal a cryptic selectivity filter binding site. Nature 547(7663), 364-368 (2017).
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