Norfluoxetine-d5 (hydrochloride) (Synonyms: Desmethylfluoxetine-d5) |
| Catalog No.GC49355 |
An internal standard for the quantification of norfluoxetine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1185132-92-6
Sample solution is provided at 25 µL, 10mM.
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Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine.1 It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A.2 Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM).1 It has been found in the tissues of fish exposed to wastewater effluent.3
1.Wong, D.T., Bymaster, F.P., Reid, L.R., et al.Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brainNeuropsychopharmacology8(4)337-344(1993) 2.Hiemke, C., and HÄrtter, S.Pharmacokinetics of selective serotonin reuptake inhibitorsPharmacol. Ther.85(1)11-28(2000) 3.Brooks, B.W., Chambliss, C.K., Stanley, J.K., et al.Determination of select antidepressants in fish from an effluent-dominated streamEnviron. Toxicol. Chem.24(2)464-469(2005)
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