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p38-α MAPK-IN-1 Catalog No.GC30158

Size Price Stock Qty
10mM*1mLinDMSO
$318.00
In stock
1mg
$101.00
In stock
5mg
$304.00
In stock
10mg
$459.00
In stock
50mg
$1,379.00
In stock
100mg
$1,930.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 443913-15-3 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CC1=CC=C(N2C(NC(NC3=CC=C(OCCN4CCOCC4)C=C3)=O)=CC(C(C)(C)C)=N2)C=C1
Formula C27H35N5O3 M.Wt 477.6
Solubility DMSO : ≥ 100 mg/mL (209.38 mM);H2O : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.

p38-α MAPK-IN-1 (Compound 12) is an inhibitor of MAPK14 (p38-α)>, with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].

[1]. Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53(1):357-67.