PKD

Protein kinase D (PKD) are a family of serine/threonine kinases comprised of three different but closely related members of Calmodulin-dependent protein kinases, including PKD1, PKD2 and PKD3, that are involved in fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription. All PKD protein kinases are diacylglycerol (DAG) receptors characterized by the presence of a highly conserved N-terminal regulatory domain, which consists of two zinc finger-like cysteine-rich domains, and an autoinhibitory pleckstrin homology (PH) domain. DAG is able to bind to the cysteine-rich domain of PKD enzymes, which is crucial for kinase activation.

Products for PKD

Cat.No. Product Name Information
GC68537 3-IN-PP1
3-IN-PP1 is a protein kinase D (PKD) inhibitor. It has effective and broad PKD inhibitory activity against PKD1, PKD2, and PKD3 with IC50 values of 108, 94, and 108 nM respectively. Additionally, 3-IN-PP1 is a broad-spectrum anticancer agent that inhibits the growth of various tumor cells. It can be used in cancer research.
GC13589 CID 755673 PKD inhibitor
GC43326 CRT0066101 (hydrochloride) Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.
GC35750 CRT0066101 dihydrochloride CRT0066101 dihydrochloride is a potent and specific PKD inhibitor with IC50 values of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.
GC14355 CRT5

CRT0066051
PKD1, PKD2, and PKD3 inhibitor
GC11319 kb NB 142-70 A selective PKD inhibitor