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Home >> Signaling Pathways >> Apoptosis >> PKD

PKD

Protein kinase D (PKD) are a family of serine/threonine kinases comprised of three different but closely related members of Calmodulin-dependent protein kinases, including PKD1, PKD2 and PKD3, that are involved in fission of vesicles at the Golgi compartment, coordination of cell migration and invasion, and regulation of gene transcription. All PKD protein kinases are diacylglycerol (DAG) receptors characterized by the presence of a highly conserved N-terminal regulatory domain, which consists of two zinc finger-like cysteine-rich domains, and an autoinhibitory pleckstrin homology (PH) domain. DAG is able to bind to the cysteine-rich domain of PKD enzymes, which is crucial for kinase activation.

Products for  PKD

  1. Cat.No. Product Name Information
  2. GC68537 3-IN-PP1

    3-IN-PP1 is a protein kinase D (PKD) inhibitor. It has effective and broad PKD inhibitory activity against PKD1, PKD2, and PKD3 with IC50 values of 108, 94, and 108 nM respectively. Additionally, 3-IN-PP1 is a broad-spectrum anticancer agent that inhibits the growth of various tumor cells. It can be used in cancer research.

     3-IN-PP1 Chemical Structure
  3. GC13589 CID 755673 PKD inhibitor CID 755673 Chemical Structure
  4. GC13838 CRT 0066101 PKD inhibitor CRT 0066101 Chemical Structure
  5. GC35750 CRT0066101 dihydrochloride CRT0066101 dihydrochloride is a potent and specific PKD inhibitor with IC50 values of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively. CRT0066101 dihydrochloride Chemical Structure
  6. GC14355 CRT5 PKD1, PKD2, and PKD3 inhibitor CRT5 Chemical Structure
  7. GC11319 kb NB 142-70 A selective PKD inhibitor kb NB 142-70 Chemical Structure

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