Thymidylate Synthase

Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.

Products for Thymidylate Synthase

Cat.No. Product Name Information
GC64726 10-Formyl-5,8-dideazafolic acid 10-Formyl-5,8-dideazafolic acid is a thymidylate synthase inhibitor.
GC11099 Doxifluridine

5DFUR, Ro 219738
oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU)
GC62645 Fosifloxuridine nafalbenamide

NUC-3373
Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy.
GC14681 Nolatrexed (AG-337)

AG337
Nolatrexed (AG-337) (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed (AG-337) (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.
GC11610 Pemetrexed
Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis.
GC17694 Pemetrexed disodium hemipenta hydrate
GC17750 Raltitrexed

ICI-D 1694, ZD 1694

Thymidylate synthase inhibitor
GC19348 TAS-102

TAS-102
TAS-102 (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of TAS-102 (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). TAS-102 (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.
GC37798 Tipiracil Tipiracil is a thymidine phosphorylase (TPase) inhibitor.
GC13803 Triflurdine (Viroptic)

NSC 75520, NSC 529182, TFT, Trifluridine
Triflurdine (Viroptic) (Trifluorothymidine; 5-Trifluorothymidine; TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Triflurdine (Viroptic) is an antiviral drug for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity.