GPCR19
GPCR19 is a G protein-coupled receptor for bile acid. Activation of this receptor induces its internalization and the production of intreacelluar cAMP. It is Involved in the suppression of macrophage function and regulation of energy homeostasis.
Products for GPCR19
- Cat.No. Product Name Information
- GC40637 BAR501 BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1; EC50 = 1 μM) that lacks activity at the farnesoid X receptor (FXR).
- GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
- GC33762 Deoxycholic acid (Cholanoic Acid) A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
- GC33768 Deoxycholic acid sodium salt (Sodium deoxycholate) Deoxycholic acid sodium salt (Sodium deoxycholate) (sodium deoxycholate), a bile acid, is a by-product of intestinal metabolism, that activates the G protein-coupled bile acid receptorTGR5.
- GC46012 DY 268 An FXR antagonist
- GN10489 Hyodeoxycholic acid
- GC32742 INT-767 INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively.
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GC13681
INT-777
INT-777 is a novel specific semisynthetic TGR5 agonist used for alleviating cardiomyocyte injury and improving cognitive impairment and synaptic dysfunction in mice model of AD.
- GC36319 INT-777 R-enantiomer INT-777 R-enantiomer is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
- GC31370 SB756050 A TGR5 agonist
- GC34775 SBI-115 SBI-115 is a TGR5 (GPCR19) antagonist.
- GC16363 TGR5 Receptor Agonist TGR5 G-protein receptor agonist