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Home >> Signaling Pathways >> GPCR/G protein >> GPCR19

GPCR19

GPCR19 is a G protein-coupled receptor for bile acid. Activation of this receptor induces its internalization and the production of intreacelluar cAMP. It is Involved in the suppression of macrophage function and regulation of energy homeostasis.

Products for  GPCR19

  1. Cat.No. Product Name Information
  2. GC40637 BAR501 BAR501 is a selective agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1; EC50 = 1 μM) that lacks activity at the farnesoid X receptor (FXR). BAR501 Chemical Structure
  3. GC30565 BAR502 A dual agonist of GP-BAR1 and FXR BAR502 Chemical Structure
  4. GC33762 Deoxycholic acid (Cholanoic Acid)

    Cholanoic Acid, DCA, NSC 8797

     Deoxycholic acid (Cholanoic Acid) is a bile acid and a byproduct of intestinal metabolism that can activate the G protein-coupled bile acid receptor TGR5. Deoxycholic acid (Cholanoic Acid) Chemical Structure
  5. GC33768 Deoxycholic acid sodium salt (Sodium deoxycholate) Deoxycholic acid sodium salt (Sodium deoxycholate) is a bile acid that is a byproduct of intestinal metabolism and can activate the G protein-coupled bile acid receptor TGR5. Deoxycholic acid sodium salt (Sodium deoxycholate) Chemical Structure
  6. GC46012 DY 268 An FXR antagonist DY 268 Chemical Structure
  7. GN10489 Hyodeoxycholic acid

    α-Hyodeoxycholic Acid, HDCA, NSC 60672

     Hyodeoxycholic acid Chemical Structure
  8. GC32742 INT-767 INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. INT-767 Chemical Structure
  9. GC13681 INT-777

    6-EMCA, S-EMCA, HY-15677

     INT-777 is a novel specific semisynthetic TGR5 agonist used for alleviating cardiomyocyte injury and improving cognitive impairment and synaptic dysfunction in mice model of AD. INT-777 Chemical Structure
  10. GC36319 INT-777 R-enantiomer

    S-EMCA R enantiomer

     INT-777 R-enantiomer is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777. INT-777 R-enantiomer Chemical Structure
  11. GC31370 SB756050 A TGR5 agonist SB756050 Chemical Structure
  12. GC34775 SBI-115

    SBI-115 is an antagonist of the G protein-coupled bile acid receptor 1 (TGR5; GPCR19).

     SBI-115 Chemical Structure
  13. GC16363 TGR5 Receptor Agonist

    CCDC

     TGR5 G-protein receptor agonist TGR5 Receptor Agonist Chemical Structure

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