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Home >> Signaling Pathways >> Immunology/Inflammation >> SIKs

SIKs

SIKs (salt-inducible kinases) are serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis and tumor suppression etc.

Products for  SIKs

  1. Cat.No. Product Name Information
  2. GC72915 (R)-MRT199665 (R)-MRT199665 is an isomer of MRT199665. (R)-MRT199665 Chemical Structure
  3. GC33070 ARN-3236 An inhibitor of SIK2 ARN-3236 Chemical Structure
  4. GC73750 GLPG3312 GLPG3312 (Compound 28) is a selective pan-SIK inhibitor with IC50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1, SIK2 and SIK3, respectively. GLPG3312 Chemical Structure
  5. GC69169 GLPG3970

    GLPG3970 (compound 88) is a novel SIK2/SIK3 inhibitor. GLPG3970 can be used for research on inflammation and autoimmune diseases.

     GLPG3970 Chemical Structure
  6. GC11719 HG-9-91-01 HG-9-91-01 is a salt-inducible kinases (SIK) inhibitor, inhibited SIK1, SIK2, SIK3 with IC50 values of 0.92nM, 6.5nM and 19.4nM, respectively. HG-9-91-01 Chemical Structure
  7. GC62657 MRIA9 MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively. MRIA9 Chemical Structure
  8. GC39148 Pterosin B Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B Chemical Structure
  9. GC62142 WH-4-025 WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2). WH-4-025 Chemical Structure
  10. GC31645 YKL-05-099 YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 Chemical Structure
  11. GC37951 YKL-06-061 YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively. YKL-06-061 Chemical Structure
  12. GC39195 YKL-06-062 YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively. YKL-06-062 Chemical Structure

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