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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> P-gp

P-gp

P-gp (P-glycoprotein) is a ATP-binding cassette transproters which overepxressed in multidrug-resistance cancer cells. It functions in pumping drug out of cell and lower intracellular drug concentration.

Products for  P-gp

  1. Cat.No. Product Name Information
  2. GC13375 Dofequidar fumarate

    MS-209

     MDR reversal agent Dofequidar fumarate Chemical Structure
  3. GC10964 Estradiol 17-(β-D-Glucuronide) (sodium salt)

    E217G,β-Estradiol 17-(β-D-Glucuronide),17β-Estradiol 17-(β-D-Glucuronide),17β-Oestradiol 17-(β-D-Glucuronide)

     Estradiol 17-(β-D-Glucuronide) is a metabolic product of estradiol, the main female sex hormone. Estradiol 17-(β-D-Glucuronide) (sodium salt) Chemical Structure
  4. GC17065 Estradiol 3-(β-D-Glucuronide) (sodium salt)

    E23G,β-Estradiol 3-(β-D-Glucuronide),17β-Estradiol 3-(β-D-Glucuronide),17β-Oestradiol 3-(β-D-Glucuronide)

     substrate for multidrug resistance protein 2 (MRP2) Estradiol 3-(β-D-Glucuronide) (sodium salt) Chemical Structure
  5. GC25405 Evodine Evodine, a natural product extracted from Evodiae fructus (EF), is a biomarker for quality assessment of EF in the Chinese Pharmacopoeia. Evodine is a potent P-gp inhibitor. Evodine Chemical Structure
  6. GC10391 Hypophyllanthin

    NSC 619044

     P-glycoprotein (P-gp) inhibitor Hypophyllanthin Chemical Structure
  7. GC16609 LY335979 (Zosuquidar 3HCL)

    RS 33295-198; Zosuquidar trihydrochloride; LY335979; LY-335979

     Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). LY335979 (Zosuquidar 3HCL) shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research. LY335979 (Zosuquidar 3HCL) Chemical Structure
  8. GC15795 Rhodamine 123 (chloride)

    R-22420,R-302,RH123

     Rhodamine 123 (chloride) is a cell-permeable cationic fluorescent probe that specifically recognizes mitochondrial membrane potential, with maximum excitation/emission light of 507/529nm. Rhodamine 123 (chloride) Chemical Structure
  9. GC15570 Tariquidar

    XR9576

     A P-glycoprotein inhibitor Tariquidar Chemical Structure
  10. GC10928 Tariquidar methanesulfonate, hydrate A P-glycoprotein inhibitor Tariquidar methanesulfonate, hydrate Chemical Structure
  11. GC16672 Zosuquidar A modulator of P-gp Zosuquidar Chemical Structure

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