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Home >> Signaling Pathways >> Others >> FAS

FAS

Fatty Acid Synthase (FAS) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.

Fatty acid synthase of animal tissues is a complex multifunctional enzyme consisting of two identical monomers.

Products for  FAS

  1. Cat.No. Product Name Information
  2. GC15572 (+)-trans-C75

    (2R,3S)-C75

     enantiomer of C75, a fatty acid synthase (FAS) inhibitor (+)-trans-C75 Chemical Structure
  3. GC16184 (-)-trans-C75

    (2S,3R)-C75

     enantiomer of C75, a FAS inhibitor (-)-trans-C75 Chemical Structure
  4. GN10632 Betulin

    (+)-Betulin, NSC 4644, Trochol

     Betulin Chemical Structure
  5. GC34065 C75 C75 is a specific inhibitor of fatty acid synthase (FASN/FAS) with moderate inhibitory activity, showing an IC50 value of 15.53 μM. C75 Chemical Structure
  6. GC14025 Cerulenin

    Helicocerin, NSC 116069

    fatty acid synthase (FAS) inhibitor

     Cerulenin Chemical Structure
  7. GC38221 Desoxyrhaponticin

    Desoxyrhaponticin is a stilbene glycoside from the Tibetan nutritional food Rheum tanguticum Maxim. Desoxyrhaponticin is a Fatty acid synthase (FASN) inhibitor, and has apoptotic effect on human cancer cells.

     Desoxyrhaponticin Chemical Structure
  8. GC38535 Dihydrocurcumin Dihydrocurcumin Chemical Structure
  9. GC31406 FAS-IN-1 FAS-IN-1 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FAS-IN-1 Chemical Structure
  10. GC34311 FAS-IN-1 Tosylate FAS-IN-1 Tosylate Chemical Structure
  11. GC33398 FASN inhibitor 1 FASN inhibitor 1 is a fatty acid synthase (FASN) inhibitor extracted from patent US20170119786A1, compound 242A. FASN inhibitor 1 Chemical Structure
  12. GC34584 FASN-IN-1 FASN-IN-1 is a fatty acid synthase (FASN) inhibitor extracted from patent WO2015134790A1, compound 56. FASN-IN-1 Chemical Structure
  13. GC36030 FASN-IN-2

    Denifanstat; TVB-2640; ASC-40

     FASN-IN-2 (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. FASN-IN-2 Chemical Structure
  14. GC36031 Fatostatin

    125B11

     Fatostatin (125B11) is a specific inhibitor of sterol regulatory element-binding proteins (SREBP) activation, inhibiting the activation of both SREBP-1 and SREBP-2. Fatostatin Chemical Structure
  15. GC18121 Fatostatin A hydrobromide

    Fatostatin (125B11) HBr

     Fatostatin A hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin A hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin A hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin A hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice. Fatostatin A hydrobromide Chemical Structure
  16. GC31323 FGH10019

    FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 μM.

     FGH10019 Chemical Structure
  17. GC33374 HS79 HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 1.57 μM. HS79 Chemical Structure
  18. GC33346 HS80 HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM. HS80 Chemical Structure
  19. GC14316 ML-356 thioesterase domain of fatty acid synthase (FAS-TE) inhibitor ML-356 Chemical Structure
  20. GC36736 Nicodicosapent Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. Nicodicosapent Chemical Structure
  21. GC17318 Orlistat

    Ro 18-0647/002, (-)-Tetrahydrolipstatin

     Orlistat is an irreversible inhibitor of lipases in the pancreas and stomach. Orlistat Chemical Structure
  22. GN10392 Praeruptorin B Praeruptorin B Chemical Structure
  23. GC38839 Pseudoprotodioscin Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides. Pseudoprotodioscin Chemical Structure
  24. GC38710 TVB-3166 A FASN inhibitor TVB-3166 Chemical Structure
  25. GC15091 UCM05

    G28UCM

    fatty acid synthase inhibitor

     UCM05 Chemical Structure

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