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FLAP

FLAP (5-lipoxygenase activating protein) is an integral protein within the nuclear membrane and is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes.

Products for  FLAP

  1. Cat.No. Product Name Information
  2. GC31839 AM 103 AM 103 is a potent and selective FLAP inhibitor, with an IC50 value of 4.2 nM. AM 103  Chemical Structure
  3. GC62422 Atuliflapon

    AZD5718

    Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5?Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon  Chemical Structure
  4. GC12232 BAY-X 1005

    BAY X 1005; DG-031

    BAY-X 1005 (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor. BAY-X 1005  Chemical Structure
  5. GC69101 FEN1-IN-2

    FEN1-IN-2 (compound 20) is an inhibitor of flap endonuclease 1 (FEN1), with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively.

    FEN1-IN-2  Chemical Structure
  6. GC73487 FEN1-IN-5 FEN1-IN-5 (compound 12A) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=12 nM), involving in DNA repair. FEN1-IN-5  Chemical Structure
  7. GC31689 Fiboflapon (GSK2190915)

    AM803

    Fiboflapon (GSK2190915) (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood. Fiboflapon (GSK2190915)  Chemical Structure
  8. GC15506 GSK2190915 sodium salt

    GSK2190915 sodium salt; AM-803 sodium

    GSK2190915 sodium salt (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood. GSK2190915 sodium salt  Chemical Structure
  9. GC12277 MK 886

    L-663,536

    FLAP and PPARα inhibitor, inhibits leukotriene biosynthesis MK 886  Chemical Structure
  10. GC11457 MK-0591

    L-686,708, Quiflapon

    An inhibitor of FLAP MK-0591  Chemical Structure
  11. GC37059 Quiflapon sodium Quiflapon sodium (MK-591 sodium) is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor. Quiflapon sodium  Chemical Structure

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