LRRK2
LRRK2 (Leucine-rich repeat kinase 2) is an enzyme that interacts with parkin and is associated with Parkinson's disease and also Crohn's disease.
Products for LRRK2
- Cat.No. Product Name Information
- GC16731 CZC 54252 hydrochloride CZC 54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively.
- GC16038 CZC-25146 LRRK2 inhibitor
- GC35792 CZC-25146 hydrochloride CZC-25146 hydrochloride is a potent LRRK2 inhibitor with IC50 values of 4.76 nM and 6.87 nM for wild-type LRRK2 and G2019S LRRK2, respectively.
- GC64730 EB-42486 EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM).
- GC12121 GNE-7915 Potent and selective LRRK2 inhibitor
- GC36171 GNE-7915 tosylate GNE-7915 tosylate is a potent, selective and brain-penetrant inhibitor of LRRK2 with an IC50 of 9 nM.
- GC13868 GNE-9605 LRRK2 inhibitor, brain-penetrant, potent and selective
- GC15196 GNE0877 Potent and selective LRRK2 inhibitor
- GC18049 GSK2578215A LRRK2 inhibitor
- GC13098 HG-10-102-01 LRRK2 inhibitor
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GC12370
IKK-16 (hydrochloride)
IKK Inhibitor VII
IκB kinases (IKKs) inhibitor - GC12180 IKK-16 (IKK Inhibitor VII) IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.
- GC19205 JH-II-127 JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.
- GC65390 LRRK2 inhibitor 1 LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8.
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GC10809
LRRK2-IN-1
Leucine-rich repeat kinase 2 IN-1
A selective LRRK2 inhibitor -
GC69402
LRRK2-IN-7
LRRK2-IN-7 is an effective, selective, CNS-penetrant LRRK2 kinase inhibitor with an IC50 of 0.9 nM. The selectivity of LRRK2-IN-7 is over 1000-fold for other kinases, ion channels and CYP enzymes.
- GC30769 MLi-2 An LRRK2 inhibitor
- GC13850 PF-06447475 LRRK2 inhibitor
- GC64566 PF-06454589 PF-06447475 is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively.
- GC64506 PF-06456384 trihydrochloride PF-06447475 trihydrochloride is a highly potent, selective, brain penetrant LRRK2 kinase inhibitor with IC50 values of 3 nM and 11 nM for WT LRRK and G2019S LRRK2, respectively.
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GC36888
PFE-360
PF-06685360
PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo.