Ro 90-7501 |
Catalog No.GC10425
One-Click Copy Product Info
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Inhibitor of amyloid β42 (Aβ42) fibril assembly
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 293762-45-5
Sample solution is provided at 25 µL, 10mM.
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Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.[1] Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 µM).1 More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C); a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.[2] Ro 90-7501 (10 µM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesiculastomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.[2]
Reference
[1]. Bohrmann, B., Adrian, M., Dubochet, J., et al. Self-assembly ofβamyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. Journal of Structural Biology 130(2-3), 232-246 (2000).
[2]. Guo, F., Mead, J., Aliya, N., et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One 7(10), (2012).
| Cas No. | 293762-45-5 | SDF | |
| Chemical Name | 2'-(4-aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-6-amine | ||
| Canonical SMILES | NC1=CC=C2N=C(C3=CC=C4N=C(C(C=C5)=CC=C5N)NC4=C3)NC2=C1 | ||
| Formula | C20H16N6 | M.Wt | 340.39 |
| Solubility | 15 mg/ml in DMF, 10 mg/ml in DMSO, 2 mg/ml in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9378 mL | 14.689 mL | 29.3781 mL |
| 5 mM | 587.6 μL | 2.9378 mL | 5.8756 mL |
| 10 mM | 293.8 μL | 1.4689 mL | 2.9378 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)