Ro60-0175 |
Catalog No.GC64606
One-Click Copy Product Info
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Ro60-0175 is a potent and selective agonist of 5-HT2C receptor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 169675-08-5
Sample solution is provided at 25 µL, 10mM.
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Ro60-0175 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 reduces cocaine self-administration, and the ability of cocaine to reinstate responding after extinction of drug-seeking behavior[1].
Ro60-0175 (1 mg/kg; s.c.) preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1].Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); s.c., i.p.) reduces responding for cocaine and effect is reversed by SB242084[1].Ro60-0175 (0.3, 1, and 3 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) reduces responding and that this effect is prevented by SB242084 pretreatment[1].Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) significantly reduces responding on the active lever in the reinstatement group[1].Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].
[1]. Fletcher PJ, et al. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33(6):1402-1412.
| Cas No. | 169675-08-5 | SDF | |
| Formula | C11H12ClFN2 | M.Wt | 226.68 |
| Solubility | DMSO : 125 mg/mL (551.44 mM; Need ultrasonic) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.4115 mL | 22.0575 mL | 44.1151 mL |
| 5 mM | 882.3 μL | 4.4115 mL | 8.823 mL |
| 10 mM | 441.2 μL | 2.2058 mL | 4.4115 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)