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Home >> Signaling Pathways >> GPCR/G protein >> 5-HT Receptor

5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC64563 α-Methylserotonin α-Methylserotonin Chemical Structure
  3. GC11577 α-Methyl-5-hydroxytryptamine maleate

    α-Me-5-HT, α-Methyl-5-HT, α-Methyl-5-hydroxytryptamine, α-Methylserotonin

     5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate Chemical Structure
  4. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine Chemical Structure
  5. GC73658 (-)-5-HT2C agonist-3 (-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 Chemical Structure
  6. GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities. (4E)-SUN9221 Chemical Structure
  7. GC67937 (R)-Mirtazapine

    (R)-Org3770; (R)-6-Azamianserin

     (R)-Mirtazapine Chemical Structure
  8. GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron. (R,R)-Palonosetron Hydrochloride Chemical Structure
  9. GC71283 (Rac)-Rotigotine (Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. (Rac)-Rotigotine Chemical Structure
  10. GC73666 (S)-Bexicaserin (S)-Bexcaserin (compound 2) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related diseases. (S)-Bexicaserin Chemical Structure
  11. GC67989 (S)-Mirtazapine

    (S)-Org3770; (S)-6-Azamianserin

     (S)-Mirtazapine Chemical Structure
  12. GC68410 (S)-Mirtazapine-d3

    (S)-Org3770 D3; (S)-6-Azamianserin D3

     (S)-Mirtazapine-d3 Chemical Structure
  13. GC69941 (S)-Renzapride

    (S)-BRL 24924

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

     (S)-Renzapride Chemical Structure
  14. GC35011 (Z)-Thiothixene (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. (Z)-Thiothixene Chemical Structure
  15. GC12587 1-(1-Naphthyl) piperazine (hydrochloride)

    1-NP

     ligand for 5-HT receptors 1-(1-Naphthyl) piperazine (hydrochloride) Chemical Structure
  16. GC16031 1-(3-Chlorophenyl)piperazine (hydrochloride)

    3-Chlorophenylpiperazine,meta-Chlorophenylpiperazine,1-(m-Chlorophenyl)piperazine,3-CPP,mCPP

    5-HT2C/2B receptor agonist/partial agonist

     1-(3-Chlorophenyl)piperazine (hydrochloride) Chemical Structure
  17. GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective 1-Methylpsilocin Chemical Structure
  18. GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist 1-Phenylbiguanide hydrochloride Chemical Structure
  19. GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT Chemical Structure
  20. GC11176 2-Methyl-5-hydroxytryptamine hydrochloride

    2-Methyl-5-hydroxytryptamine hydrochloride; 2-Methylserotonin hydrochloride; 2-Me-HT hydrochloride

     2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-hydroxytryptamine hydrochloride Chemical Structure
  21. GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor 2-[1-(4-Piperonyl)piperazinyl]benzothiazole Chemical Structure
  22. GC15569 3-AQC 5-HT3 antagonist 3-AQC Chemical Structure
  23. GC68328 3-Hydroxy agomelatine-d3 3-Hydroxy agomelatine-d3 Chemical Structure
  24. GC16040 4F 4PP oxalate 5-HT2A antagonist 4F 4PP oxalate Chemical Structure
  25. GC14814 5-Carboxamidotryptamine maleate

    5-CT maleate

     5-HT1 agonist 5-Carboxamidotryptamine maleate Chemical Structure
  26. GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. 5-HT1A modulator 1 Chemical Structure
  27. GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity. 5-HT2 antagonist 1 Chemical Structure
  28. GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1 Chemical Structure
  29. GC71279 5-HT2A receptor agonist-3

    5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM, and with 124-fold selectivity for 5-HT2A over the structurally similar 5-HT2C receptor.

     5-HT2A receptor agonist-3 Chemical Structure
  30. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 Chemical Structure
  31. GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT3 antagonist 1 Chemical Structure
  32. GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. 5-HT3 antagonist 2 Chemical Structure
  33. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5 Chemical Structure
  34. GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. 5-HT3-In-1 Chemical Structure
  35. GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 5-HT4 antagonist 1 Chemical Structure
  36. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride Chemical Structure
  37. GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM. 5HT6-ligand-1 Chemical Structure
  38. GC30888 8-OH-DPAT (8-Hydroxy-DPAT)

    8-Hydroxy-DPAT

     8-OH-DPAT, at a pIC50 of 8.19, exhibits robust and specific agonistic activity on 5-HT1A receptors, indicating high selectivity. 8-OH-DPAT (8-Hydroxy-DPAT) Chemical Structure
  39. GC31055 Abaperidone Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. Abaperidone Chemical Structure
  40. GC35252 Adoprazine Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine Chemical Structure
  41. GC17981 Agomelatine

    S20098

     Agomelatine is a melatonin (MT) receptor agonist with Ki values of 0.1 nM and 0.12 nM for MT1 and MT2, respectively. Agomelatine is also a 5-hydroxytryptamine (5-HT) receptor antagonist with Ki values of 631 nM and 660 nM for 5-HT2C and 5-HT2B respectively. Agomelatine Chemical Structure
  42. GC35269 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride Chemical Structure
  43. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid Chemical Structure
  44. GC15153 Almotriptan Malate

    PNU 180638E

     5-HT1B/1D-receptor agonist Almotriptan Malate Chemical Structure
  45. GC31054 Alniditan (Alnitidan)

    Alnitidan

     Alniditan (Alnitidan) (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan (Alnitidan) Chemical Structure
  46. GC35301 Alosetron ((Z)-2-butenedioate) Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron ((Z)-2-butenedioate) Chemical Structure
  47. GC35302 Alosetron (Hydrochloride(1:X)) Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Hydrochloride(1:X)) Chemical Structure
  48. GC35303 Alosetron D3 Hydrochloride

    GR-68755C D3

     Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist. Alosetron D3 Hydrochloride Chemical Structure
  49. GC64265 Alosetron-13C,d3

    GR 68755-13C,d3; GR 68755X-13C,d3

     Alosetron-13C,d3 Chemical Structure
  50. GC32905 Alprenolol ((RS)-Alprenolol)

    (±)-Alprenolol, dl-Alprenolol, (RS)-Alprenolol

     Alprenolol ((RS)-Alprenolol) ((RS)-Alprenolol ((RS)-Alprenolol); dl-Alprenolol ((RS)-Alprenolol)) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol ((RS)-Alprenolol) is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. Alprenolol ((RS)-Alprenolol) Chemical Structure
  51. GC14105 Alprenolol hydrochloride β-adrenoceptor and 5-HT1A receptor antagonist. Alprenolol hydrochloride Chemical Structure
  52. GC14030 Altanserin hydrochloride 5-HT2A receptor antagonist Altanserin hydrochloride Chemical Structure
  53. GC10891 Alverine Citrate

    NSC 35459

     Drug used for functional gastrointestinal disorders Alverine Citrate Chemical Structure
  54. GC13723 Amitriptyline HCl

    NIH 10794, Ro 4-1575

     Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl Chemical Structure
  55. GC70513 Amperozide Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide Chemical Structure
  56. GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. Ansofaxine hydrochloride (LY03005) Chemical Structure
  57. GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. AP521 Chemical Structure
  58. GC72981 Apomorphine

    (-)-Apomorphine

     Apomorphine is an orally active agonist of Dopamine receptor. Apomorphine Chemical Structure
  59. GC31291 AR-A 2 (AR-A 000002)

    AR-A 000002

     AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety. AR-A 2 (AR-A 000002) Chemical Structure
  60. GC10117 Aripiprazole

    OPC 31, OPC 14597

     5-HT receptor partial agonist Aripiprazole Chemical Structure
  61. GC35386 Aripiprazole D8

    OPC-14597 D8

     Aripiprazole D8 Chemical Structure
  62. GC68687 Aripiprazole-d8

    Aripiprazole-d8 is the deuterated form of Aripiprazole.

     Aripiprazole-d8 Chemical Structure
  63. GC17525 AS 19 Potent 5-HT7 agonist AS 19 Chemical Structure
  64. GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor Asenapine Chemical Structure
  65. GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Asenapine maleate Chemical Structure
  66. GC16807 AT 1015 Long-acting 5-HT2A antagonist AT 1015 Chemical Structure
  67. GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). AVN-492 Chemical Structure
  68. GC15687 Azasetron HCl

    Y-25130

     Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron HCl Chemical Structure
  69. GC31113 Befiradol (NLX-112) Befiradol (NLX-112) (NLX-112) is a selective 5-HT1A receptor agonist. Befiradol (NLX-112) Chemical Structure
  70. GC34304 Befiradol hydrochloride (NLX-112 (hydrochloride)) Befiradol hydrochloride (NLX-112 (hydrochloride)) Chemical Structure
  71. GC15092 BGC 20-761 5-HT6 antagonist,selective and high affinity BGC 20-761 Chemical Structure
  72. GC14925 BIMU 8 5-HT4 agonist BIMU 8 Chemical Structure
  73. GC14160 Blonanserin

    AD5423, Lonasen

     Atypical antipsychotic Blonanserin Chemical Structure
  74. GC10848 BMY 7378 5-HT1A partial agonist and α1D adrenoceptor antagonist BMY 7378 Chemical Structure
  75. GC11186 Brexpiprazole

    OPC 34712

     5-HT2A, α1B-, and α2C-adrenergic receptors antagonist Brexpiprazole Chemical Structure
  76. GC68806 Brexpiprazole S-oxide-d8

    DM-3411 d8

    Brexpiprazole S-oxide-d8 is the deuterated form of Brexpiprazole S-oxide. Brexpiprazole S-oxide is the main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic drug that acts as a partial agonist of human 5-HT1A and dopamine receptors with Ki values of 0.12 nM and 0.3 nM, respectively. It also acts as an antagonist of the 5-HT2A receptor with a Ki value of 0.47 nM.

     Brexpiprazole S-oxide-d8 Chemical Structure
  77. GC71436 Brexpiprazole-d8-1 Brexpiprazole-d8-1 is the deuterium labeled Brexpiprazole. Brexpiprazole-d8-1 Chemical Structure
  78. GC16226 BRL-15572 dihydrochloride BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride Chemical Structure
  79. GC17130 BRL-54443 5-HT1E/1F receptor agonist,potent and selective BRL-54443 Chemical Structure
  80. GC30989 Bromperidol (R-11333) Bromperidol (R-11333) (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol (R-11333) Chemical Structure
  81. GC11191 Buspirone HCl

    MJ9022-1

     Buspirone HCl is a 5-HT1A receptor agonist. Buspirone HCl Chemical Structure
  82. GC11231 BW 723C86 hydrochloride BW 723C86 hydrochloride is a potent and a selective 5-HT2B receptor agonist. BW 723C86 hydrochloride Chemical Structure
  83. GC35610 Cariprazine hydrochloride

    RGH-188

     An atypical antipsychotic Cariprazine hydrochloride Chemical Structure
  84. GC46007 Cariprazine-d6 An internal standard for the quantification of cariprazine Cariprazine-d6 Chemical Structure
  85. GC63961 Cerlapirdine

    SAM-531; PF-05212365

     Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine Chemical Structure
  86. GC30280 Chlorpromazine D6 hydrochloride

    CPZ-d6

     An internal standard for the quantification of chlorpromazine Chlorpromazine D6 hydrochloride Chemical Structure
  87. GC14216 Chlorpromazine HCl

    CPZ

     Chlorpromazine HCl is an orally effective, blood-brain-permeable phenothiazine antipsychotic that can effectively antagonize D2 dopamine receptors and 5-HT2A and has a strong sedative effect. Chlorpromazine HCl Chemical Structure
  88. GC16135 Cinanserin hydrochloride

    SQ 10,643

     5-HT2 antagonist Cinanserin hydrochloride Chemical Structure
  89. GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors Cinitapride Hydrogen Tartrate Chemical Structure
  90. GC38753 cis-Urocanic acid cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid Chemical Structure
  91. GC13533 Cisapride 5-HT4 receptor agonist Cisapride Chemical Structure
  92. GC25259 Cisapride hydrate

    Propulsid, Alimix, Propulsin, Enteropride, Kinestase

     Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic. Cisapride hydrate Chemical Structure
  93. GC13583 CJ 033466 5-HT4 partial agonist CJ 033466 Chemical Structure
  94. GC31037 Clocapramine (Clocarpramine)

    Clocarpramine; 3-Chlorocarpipramine

     Clocapramine (Clocarpramine) Chemical Structure
  95. GC15107 Clomipramine HCl Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine HCl Chemical Structure
  96. GC11802 CP 135807 5-HT1D receptor agonist CP 135807 Chemical Structure
  97. GC10068 CP 93129 dihydrochloride 5-HT1B agonist, potent and highly selective CP 93129 dihydrochloride Chemical Structure
  98. GC16653 CP 94253 hydrochloride 5-HT1B agonist CP 94253 hydrochloride Chemical Structure
  99. GC38760 Cyamemazine Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine Chemical Structure
  100. GC10743 Cyclobenzaprine HCl

    MK-130

     Cyclobenzaprine HCl (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine HCl Chemical Structure
  101. GC65565 Cyproheptadine Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine Chemical Structure

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