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5-HT Receptor

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

Products for  5-HT Receptor

  1. Cat.No. Product Name Information
  2. GC64563 α-Methylserotonin α-Methylserotonin  Chemical Structure
  3. GC11577 α-Methyl-5-hydroxytryptamine maleate 5-HT2B receptor agonist α-Methyl-5-hydroxytryptamine maleate  Chemical Structure
  4. GC68210 (+)-Norfenfluramine (+)-Norfenfluramine  Chemical Structure
  5. GC32644 (4E)-SUN9221 (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities. (4E)-SUN9221  Chemical Structure
  6. GC67937 (R)-Mirtazapine (R)-Mirtazapine  Chemical Structure
  7. GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron. (R,R)-Palonosetron Hydrochloride  Chemical Structure
  8. GC67989 (S)-Mirtazapine (S)-Mirtazapine  Chemical Structure
  9. GC68410 (S)-Mirtazapine-d3 (S)-Mirtazapine-d3  Chemical Structure
  10. GC69941 (S)-Renzapride

    (S)-Renzapride ((S)-BRL 24924) is an isomer of Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. It also acts as an antagonist for the 5HT2b and 5HT3 receptors. Renzapride can be used in research on constipation-predominant irritable bowel syndrome (C-IBS).

    (S)-Renzapride  Chemical Structure
  11. GC35011 (Z)-Thiothixene (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. (Z)-Thiothixene  Chemical Structure
  12. GC12587 1-(1-Naphthyl) piperazine (hydrochloride) ligand for 5-HT receptors 1-(1-Naphthyl) piperazine (hydrochloride)  Chemical Structure
  13. GC16031 1-(3-Chlorophenyl)piperazine (hydrochloride)

    5-HT2C/2B receptor agonist/partial agonist

    1-(3-Chlorophenyl)piperazine (hydrochloride)  Chemical Structure
  14. GC14607 1-Methylpsilocin 5-HT2C agonist,potent and selective 1-Methylpsilocin  Chemical Structure
  15. GC16876 1-Phenylbiguanide hydrochloride 5-HT3 receptor agonist 1-Phenylbiguanide hydrochloride  Chemical Structure
  16. GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT  Chemical Structure
  17. GC11176 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-hydroxytryptamine hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-hydroxytryptamine hydrochloride  Chemical Structure
  18. GC14959 2-[1-(4-Piperonyl)piperazinyl]benzothiazole 5-HT4 receptor 2-[1-(4-Piperonyl)piperazinyl]benzothiazole  Chemical Structure
  19. GC15569 3-AQC 5-HT3 antagonist 3-AQC  Chemical Structure
  20. GC68328 3-Hydroxy agomelatine-d3 3-Hydroxy agomelatine-d3  Chemical Structure
  21. GC16040 4F 4PP oxalate 5-HT2A antagonist 4F 4PP oxalate  Chemical Structure
  22. GC14814 5-Carboxamidotryptamine maleate 5-HT1 agonist 5-Carboxamidotryptamine maleate  Chemical Structure
  23. GC31234 5-HT1A modulator 1 5-HT1A modulator 1 displays very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. 5-HT1A modulator 1  Chemical Structure
  24. GC32655 5-HT2 antagonist 1 5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity. 5-HT2 antagonist 1  Chemical Structure
  25. GC32664 5-HT2A antagonist 1 5-HT2A antagonist 1 is a 5-HT2A antagonist extracted from patent US5728835A and JP 1007727. 5-HT2A antagonist 1  Chemical Structure
  26. GC65568 5-HT2B antagonist-1 5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1  Chemical Structure
  27. GC31263 5-HT3 antagonist 1 5-HT3 antagonist 1 is a potent and selective antagonist of serotonin 3 (5-HT3) receptor. 5-HT3 antagonist 1  Chemical Structure
  28. GC31247 5-HT3 antagonist 2 5-HT3 antagonist 2 is a 5-HT3 receptor antagonist. 5-HT3 antagonist 2  Chemical Structure
  29. GC65983 5-HT3 antagonist 5 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice. 5-HT3 antagonist 5  Chemical Structure
  30. GC31227 5-HT3-In-1 5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. 5-HT3-In-1  Chemical Structure
  31. GC30314 5-HT4 antagonist 1 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 5-HT4 antagonist 1  Chemical Structure
  32. GC64182 5-Methoxytryptamine hydrochloride 5-Methoxytryptamine hydrochloride  Chemical Structure
  33. GC31296 5HT6-ligand-1 5HT6-ligand-1 is a potent 5-HT6 receptor ligand with a Ki of 1.43 nM. 5HT6-ligand-1  Chemical Structure
  34. GC30888 8-OH-DPAT (8-Hydroxy-DPAT) 8-OH-DPAT (8-Hydroxy-DPAT) is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT (8-Hydroxy-DPAT) weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5). 8-OH-DPAT (8-Hydroxy-DPAT)  Chemical Structure
  35. GC31055 Abaperidone Abaperidone is a potent antagonist of 5-HT2A?receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM. Abaperidone  Chemical Structure
  36. GC35252 Adoprazine Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine  Chemical Structure
  37. GC17981 Agomelatine MT1/MT2 / 5-HT2C agonist Agomelatine  Chemical Structure
  38. GC35269 Agomelatine hydrochloride Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride  Chemical Structure
  39. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine L(+)-Tartaric acid (S-20098 L(+)-Tartaric acid) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine L(+)-Tartaric acid  Chemical Structure
  40. GC15153 Almotriptan Malate 5-HT1B/1D-receptor agonist Almotriptan Malate  Chemical Structure
  41. GC31054 Alniditan (Alnitidan) Alniditan (Alnitidan) (Alnitidan) is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan (Alnitidan)  Chemical Structure
  42. GC35301 Alosetron ((Z)-2-butenedioate) Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron ((Z)-2-butenedioate)  Chemical Structure
  43. GC35302 Alosetron (Hydrochloride(1:X)) Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Hydrochloride(1:X))  Chemical Structure
  44. GC35303 Alosetron D3 Hydrochloride Alosetron D3 Hydrochloride (GR-68755C D3) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist. Alosetron D3 Hydrochloride  Chemical Structure
  45. GC64265 Alosetron-13C,d3 Alosetron-13C,d3  Chemical Structure
  46. GC32905 Alprenolol ((RS)-Alprenolol) Alprenolol ((RS)-Alprenolol) ((RS)-Alprenolol ((RS)-Alprenolol); dl-Alprenolol ((RS)-Alprenolol)) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol ((RS)-Alprenolol) is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent. Alprenolol ((RS)-Alprenolol)  Chemical Structure
  47. GC14105 Alprenolol hydrochloride β-adrenoceptor and 5-HT1A receptor antagonist. Alprenolol hydrochloride  Chemical Structure
  48. GC14030 Altanserin hydrochloride 5-HT2A receptor antagonist Altanserin hydrochloride  Chemical Structure
  49. GC10891 Alverine Citrate Drug used for functional gastrointestinal disorders Alverine Citrate  Chemical Structure
  50. GC13723 Amitriptyline HCl Amitriptyline HCl is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline HCl  Chemical Structure
  51. GC31207 Ansofaxine hydrochloride (LY03005) Ansofaxine hydrochloride (LY03005) (LY03005; LPM570065) is a triple reuptake inhibitor; inhibits serotonin, dopamine and norepinephrine reuptake with IC50 values of 723, 491 and 763 nM, respectively. Ansofaxine hydrochloride (LY03005)  Chemical Structure
  52. GC31134 AP521 AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. AP521  Chemical Structure
  53. GC31291 AR-A 2 (AR-A 000002) AR-A 2 (AR-A 000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 (AR-A 000002) can be used in the research of depression and anxiety. AR-A 2 (AR-A 000002)  Chemical Structure
  54. GC10117 Aripiprazole 5-HT receptor partial agonist Aripiprazole  Chemical Structure
  55. GC35386 Aripiprazole D8 Aripiprazole D8  Chemical Structure
  56. GC68687 Aripiprazole-d8

    Aripiprazole-d8 is the deuterated form of Aripiprazole.

    Aripiprazole-d8  Chemical Structure
  57. GC17525 AS 19 Potent 5-HT7 agonist AS 19  Chemical Structure
  58. GC11824 Asenapine Inhibits adrenergic receptor/5-HT receptor Asenapine  Chemical Structure
  59. GC63819 Asenapine maleate Asenapine maleate is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic. Asenapine maleate  Chemical Structure
  60. GC16807 AT 1015 Long-acting 5-HT2A antagonist AT 1015  Chemical Structure
  61. GC30907 AVN-492 AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to 5-HT6R (Ki=91 pM). AVN-492  Chemical Structure
  62. GC15687 Azasetron HCl Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron HCl  Chemical Structure
  63. GC31113 Befiradol (NLX-112) Befiradol (NLX-112) (NLX-112) is a selective 5-HT1A receptor agonist. Befiradol (NLX-112)  Chemical Structure
  64. GC34304 Befiradol hydrochloride (NLX-112 (hydrochloride)) Befiradol hydrochloride (NLX-112 (hydrochloride))  Chemical Structure
  65. GC15092 BGC 20-761 5-HT6 antagonist,selective and high affinity BGC 20-761  Chemical Structure
  66. GC14925 BIMU 8 5-HT4 agonist BIMU 8  Chemical Structure
  67. GC14160 Blonanserin Atypical antipsychotic Blonanserin  Chemical Structure
  68. GC10848 BMY 7378 5-HT1A partial agonist and α1D adrenoceptor antagonist BMY 7378  Chemical Structure
  69. GC11186 Brexpiprazole 5-HT2A, α1B-, and α2C-adrenergic receptors antagonist Brexpiprazole  Chemical Structure
  70. GC16226 BRL-15572 dihydrochloride BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride  Chemical Structure
  71. GC17130 BRL-54443 5-HT1E/1F receptor agonist,potent and selective BRL-54443  Chemical Structure
  72. GC30989 Bromperidol (R-11333) Bromperidol (R-11333) (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol (R-11333)  Chemical Structure
  73. GC11191 Buspirone HCl Buspirone HCl is a 5-HT1A receptor agonist. Buspirone HCl  Chemical Structure
  74. GC11231 BW 723C86 hydrochloride BW 723C86 hydrochloride is a potent and a selective 5-HT2B receptor agonist. BW 723C86 hydrochloride  Chemical Structure
  75. GC35610 Cariprazine hydrochloride An atypical antipsychotic Cariprazine hydrochloride  Chemical Structure
  76. GC46007 Cariprazine-d6 An internal standard for the quantification of cariprazine Cariprazine-d6  Chemical Structure
  77. GC63961 Cerlapirdine Cerlapirdine (SAM-531, PF-05212365) is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine  Chemical Structure
  78. GC30280 Chlorpromazine D6 hydrochloride An internal standard for the quantification of chlorpromazine Chlorpromazine D6 hydrochloride  Chemical Structure
  79. GC14216 Chlorpromazine HCl

    dopamine receptor antagonist

    Chlorpromazine HCl  Chemical Structure
  80. GC16135 Cinanserin hydrochloride 5-HT2 antagonist Cinanserin hydrochloride  Chemical Structure
  81. GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors Cinitapride Hydrogen Tartrate  Chemical Structure
  82. GC38753 cis-Urocanic acid cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid  Chemical Structure
  83. GC13533 Cisapride 5-HT4 receptor agonist Cisapride  Chemical Structure
  84. GC25259 Cisapride hydrate Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic. Cisapride hydrate  Chemical Structure
  85. GC13583 CJ 033466 5-HT4 partial agonist CJ 033466  Chemical Structure
  86. GC31037 Clocapramine (Clocarpramine) Clocapramine (Clocarpramine)  Chemical Structure
  87. GC15107 Clomipramine HCl Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine HCl  Chemical Structure
  88. GC11802 CP 135807 5-HT1D receptor agonist CP 135807  Chemical Structure
  89. GC10068 CP 93129 dihydrochloride 5-HT1B agonist, potent and highly selective CP 93129 dihydrochloride  Chemical Structure
  90. GC16653 CP 94253 hydrochloride 5-HT1B agonist CP 94253 hydrochloride  Chemical Structure
  91. GC38760 Cyamemazine Cyamemazine is a neuroleptic agent that contains the phenothiazine chromophore. Cyamemazine  Chemical Structure
  92. GC10743 Cyclobenzaprine HCl Cyclobenzaprine HCl (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine HCl  Chemical Structure
  93. GC65565 Cyproheptadine Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine  Chemical Structure
  94. GC43353 Cyproheptadine (hydrochloride hydrate) Cyproheptadine (hydrochloride hydrate) is an antihistamine and is an antagonist of serotonin and histamine2. Cyproheptadine (hydrochloride hydrate)  Chemical Structure
  95. GC10698 Cyproheptadine hydrochloride serotonin and histamine antagonist as well as antimuscarinic reagent Cyproheptadine hydrochloride  Chemical Structure
  96. GC17061 Dapoxetine HCl Selective serotonin reuptake inhibitor Dapoxetine HCl  Chemical Structure
  97. GC33722 Deramciclane (EGIS-3886) Deramciclane (EGIS-3886) has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist. Deramciclane (EGIS-3886)  Chemical Structure
  98. GC11570 Desvenlafaxine serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor Desvenlafaxine  Chemical Structure
  99. GC14262 Desvenlafaxine Succinate serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor Desvenlafaxine Succinate  Chemical Structure
  100. GC14558 Dihydroergotamine mesylate Partial α-adrenergic agonist,partial D2 dopaminergic receptor agonist, competitive 5-HT antagonist. Dihydroergotamine mesylate  Chemical Structure
  101. GC13390 DOB hydrochloride Selective 5-HT2 receptor agonist DOB hydrochloride  Chemical Structure

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