(RS)-3,5-DHPG (Synonyms: DHPG) |
| Catalog No.GC15342 |
DHPG ((RS)-3,5-DHPG) is an amino acid that is a selective potent agonist for group I mGluR (mGluR 1 and mGluR 5) and has no effect on Group II and III mGluR.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 19641-83-9
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
DHPG ((RS)-3,5-DHPG) is an amino acid that is a selective potent agonist for group I mGluR (mGluR 1 and mGluR 5) and has no effect on Group II and III mGluR [1，6]. DHPG ((RS)-3,5-DHPG) is also a potent antagonist of mGluRs associated with phospholipase D[2].
(RS)-3,5-DHPG (10µM) treatment induced MÜller cell gliosis, as evidenced by enhanced GFAP expression. In addition, (RS)-3,5-DHPG (10 and 100µM) treatment induced a transient decrease in Kir4.1 mRNA expression in the cells. Activation of mGluR I by (RS)-3,5-DHPG may decrease the number of functional Kir4.1 channels in purified cultured rat retinal MÜller cells through modulating Kir4.1 protein and mRNA, thus contributing to MÜller cell gliosis[5].
Impairments of spatial memory induced by bilateral infusions of (RS)-3,5-DHPG (50 µmol) into the CA1 area. Dose-dependent changes in spatial memory induced by (RS)-3,5-DHPG infusion. Pre-infusion of MPEP or CID755673 prevented impairments of spatial memory induced by (RS)-3,5-DHPG infusion[3]. Hippocampal GPR30 expression was reduced in middle-aged mice compared with young adult mice. a group I metabotropic glutamate receptor (mGluR) agonist (RS)-3,5-DHPG -induced long-term depression in mossy fiber-cornu ammonis 3 (MF-CA3) synapses but not SC-CA1 synapses was facilitated in brain slices from G1-treated middle-aged mice[4]. (RS)-3,5-DHPG elicited acute mechanical allodynia and thermal hyperalgesia in naÏve mice from 1 h to 12 h following intrathecal (central/spinal) administration.The attenuation of intrathecal (RS)-3,5-DHPG -evoked acute pain by artesunate therapy in rats[7].
References:
[1]: Winder DG, Conn PJ. Metabotropic glutamate receptor (mGluR)-mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64(2):592-9. doi: 10.1046/j.1471-4159.1995.64020592.x. PMID: 7830052.
[2]: Pellegrini-Giampietro DE, Torregrossa SA, Moroni F. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118(4):1035-43. doi: 10.1111/j.1476-5381.1996.tb15503.x. PMID: 8799579; PMCID: PMC1909512.
[3]: Wang W, Duclot F, et,al. Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats. PLoS One. 2018 Apr 3;13(4):e0195095. doi: 10.1371/journal.pone.0195095. PMID: 29614089; PMCID: PMC5882104.
[4]: Xu W, Cao J, et,al. GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice. Neurobiol Learn Mem. 2018 Mar;149:10-19. doi: 10.1016/j.nlm.2018.02.005. Epub 2018 Feb 6. PMID: 29421611.
[5]: Gao F, Li F, et,al. Group I metabotropic glutamate receptor agonist DHPG modulates Kir4.1 protein and mRNA in cultured rat retinal MÜller cells. Neurosci Lett. 2015 Feb 19;588:12-7. doi: 10.1016/j.neulet.2014.12.048. Epub 2014 Dec 27. PMID: 25549543.
[6]: Ito I, Kohda A, et,al. 3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors. Neuroreport. 1992 Nov;3(11):1013-6. PMID: 1362358.
[7]: Zhang L, Zhao Y, et,al.Artesunate Reduces Remifentanil-induced Hyperalgesia and Peroxiredoxin-3 Hyperacetylation via Modulating Spinal Metabotropic Glutamate Receptor 5 in Rats. Neuroscience. 2022 Apr 1;487:88-98. doi: 10.1016/j.neuroscience.2022.01.003. Epub 2022 Jan 11. PMID: 35026318.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *