Salvianolic acid B (Synonyms: Lithospermate B) |
| Catalog No.GN10344 |
Salvianolic acid B is a water-soluble phenolic compound extracted from Salvia miltiorrhiza, which has many pharmacological effects, including anti-tumor, anti-inflammation and anti-oxidation. Salvianolic acid B can cross the blood-brain barrier and directly act on the central nervous system.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115939-25-8,121521-90-2
Sample solution is provided at 25 µL, 10mM.
Salvianolic acid B is a water-soluble phenolic compound extracted from Salvia miltiorrhiza, which has many pharmacological effects, including anti-tumor, anti-inflammation and anti-oxidation. Salvianolic acid B can cross the blood-brain barrier and directly act on the central nervous system [1-4].
Amyloid beta protein fragment 1-40 (Aβ40) shows obvious toxic effects after incubation of PC12 cells for 30 h, and Salvianolic acid B (10nM and 100nM) can significantly reduce the toxic effects of Aβ40 [2]. Salvianolic acid B can inhibit the growth of JHU-022 and JHU-013 cells with IC50 values of 18 and 50μM, respectively. Treatment of JHU-022 cells with different concentrations of Salvianolic acid B (12.5-125μM) for 24 h reduced the level of cycooxygenase-2 (COX-2) protein by 50-61% [3].
Salvianolic acid B (80mg/kg) can inhibit tumor growth in nude mouse model of JHU-013 cell xenotransplantation, and the average tumor weight of Salvianolic acid B treatment group is significantly lower than that of untreated group [3]. In the rat model of depression induced by chronic mild stress (CMS), Salvianolic acid B (30mg/kg) can significantly increase the sucrose preference of rats, reduce the rest time of rats in the forced swimming experiment, and improve the depression-like behavior of rats [4].
References:
[1]Guo P, Wang S, Liang W, et al. Salvianolic acid B reverses multidrug resistance in HCT‑8/VCR human colorectal cancer cells by increasing ROS levels[J]. Molecular Medicine Reports, 2017, 15(2): 724-730.
[2] Tang MK, Zhang JT. Salvianolic acid B inhibits fibril formation and neurotoxicity of amyloid beta-protein in vitro. Acta Pharmacol Sin. 2001 Apr;22(4):380-4.
[3] Hao Y, Xie T, Korotcov A, et al. Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivovia cyclooxygenase-2 and apoptotic pathways[J]. International Journal of Cancer, 2009, 124(9): 2200-2209.
[4] Liao D, Chen Y, Guo Y, Wang C, Liu N, Gong Q, Fu Y, Fu Y, Cao L, Yao D, Jiang P. Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway. J Inflamm Res. 2020 May 12;13:195-206.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *