Senazodan |
| Catalog No.GC32526 |
Senazodan (MCI 154) is a Ca2+ sensitiser, and also shows inhibition effect on PDE III.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 98326-32-0
Sample solution is provided at 25 µL, 10mM.
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Senazodan is a Ca2+ sensitiser, and also shows inhibition effect on PDE III.
Senazodan seems to affect directly the actin-myosin crossbridge kinetics, and increase myosin ATPase activity[1]. Senazodan produces a concentration-dependent increase in tension development. Senazodan enhance Ca2+ binding to myofilaments and to purified cardiac troponin C. Senazodan also enhances contractility in guinea-pig papillary muscles by inhibiting PDE III[2].
[1]. Lehtonen LA, et al. Pharmacokinetics and pharmacodynamics of intravenous inotropic agents. Clin Pharmacokinet. 2004;43(3):187-203. [2]. Erhardt L. An emerging role for calcium sensitisation in the treatment of heart failure. Expert Opin Investig Drugs. 2005 Jun;14(6):659-70.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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