SPB |
| Catalog No.GC33619 |
SPB is a drug-linker conjugate for ADC with potent anti-inflammatory activity by using Xanthotoxol, linked via the ADC linker.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 858128-57-1
Sample solution is provided at 25 µL, 10mM.
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SPB is a key component of pulmonary surfactant, essential for normal lung function.
Human SP-B gene but not mouse SP-B is expressed in the lung of hTG SP-B-C and SP-B-T mice. For infected SP-B-C mice, the levels of bioluminescence increase rapidly from 0 to 24h after infection, remains high between 24 and 32 h, and then decreases; the bioluminescence levels are significantly lower (p<0.01) in the CMC2.24 treated group from 24 to 48 h after infection. In infected SP-B-T mice, the peak time of bioluminescence is at 12 h after infection, then the level decreases slowly. Lung tissues from of infected SP-B-C mice showed more apoptotic cells compared to infected SP-B-T mice. CMC2.24 treated SP-B-C and SP-B-T mice have decreased MMP-2, -9, and -12 activities compared to their respective untreated groups[1].
[1]. Xu Y, et al. DIFFERENTIAL SUSCEPTIBILITY OF HUMAN SP-B GENETIC VARIANTS ON LUNG INJURY CAUSED BY BACTERIAL PNEUMONIA AND THE EFFECT OF A CHEMICALLY MODIFIED CURCUMIN. Shock. 2016 Apr;45(4):375-84.
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