Tenosal |
Catalog No.GC31910
One-Click Copy Product Info
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Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 95232-68-1
Sample solution is provided at 25 µL, 10mM.
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Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties.
Tenosal is a new compound obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid and displays anti-inflammatory, analgesic and antipyretic properties. Extraction recovery measured is on average 95.75% for Tenosal, 98.71% for salicylic acid (SA) and 91.11% for TA. In the whole analysis of Tenosal extracted from plasma, the inter-assay coefficient of variation (C.V.) ranges from 1.00 to 5.86% and the intra assay C.V. is 5.01%. The administration of Tenosal allows a higher bioavailability of SA to be achieved than after dosing with ASA[1].
[1]. Lucarelli C, et al. Evaluation of 2-(2-thiophenecarboxy)benzoic acid and related active metabolites in biological samples. J Chromatogr. 1992 Jan 3;573(1):150-3.
Animal experiment: | Both sexes of albino Sprague-Dawley rats (175 to 200 g body weight) are used for the experiment. Before the trial the animals are caged for seven days at 21 to 22°C and 55 to 75% relative humidity with a cycle of 12 h light-12 h dark. The animals are orally treated with Tenosal (300 mg/kg) or ASA (220 mg/kg) by a gastric gavage, both substances being suspended in 2% arabic gum. Six animals per group are killed at times 0 (baseline), 0.5, 1, 2, 4, 8, 16 and 24 h. Heparinized blood is sampled and centrifuged to obtain plasma. Liver, kidneys, lungs, myocardium, gastric wall and intestinal wall are also sampled from the animals killed 0, 1, 2, 4, 8 and 16 h after dosing. All the samples are stored in a freezer at -20°C[1]. |
References: [1]. Lucarelli C, et al. Evaluation of 2-(2-thiophenecarboxy)benzoic acid and related active metabolites in biological samples. J Chromatogr. 1992 Jan 3;573(1):150-3. | |
| Cas No. | 95232-68-1 | SDF | |
| Canonical SMILES | O=C(C1=CC=CS1)OC2=CC=CC=C2C(O)=O | ||
| Formula | C12H8O4S | M.Wt | 248.25 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.0282 mL | 20.141 mL | 40.282 mL |
| 5 mM | 805.6 μL | 4.0282 mL | 8.0564 mL |
| 10 mM | 402.8 μL | 2.0141 mL | 4.0282 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)