Thujopsene (Synonyms: NSC 44707, cis-(-)-Thujopsene) |
| Catalog No.GC49503 |
A sesquiterpene with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 470-40-6
Sample solution is provided at 25 µL, 10mM.
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Thujopsene is a sesquiterpene that has been found in T. dolabrata and has diverse biological activities.1,2,3,4,5 It inhibits the Na+/K+-ATPase (IC50 = 25.9 µg/ml) and cytochrome P450 (CYP) isoform CYP2B6 (Ki = 0.8 µM).1,2 Thujopsene is active against Gram-positive and Gram-negative bacteria, including S. aureus, M. luteus, and S. typhimurium (MICs = 25-50 µg/ml).1 It inhibits antigen-induced β-hexosaminidase release from IgE-sensitized RBL-2H3 mast cells (IC50 = 25.1 µM) and is cytotoxic to A549 non-small cell lung cancer (NSCLC) cells with an LC50 value of 35.27 µg/ml.3,4 Thujopsene induces mortality in the mites D. farniae and T. putrescentiae (LC50s = 9.82 and 10.92 µg/cm2, respectively).5
1.Oh, I., Yang, W.-Y., Park, J., et al.In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrataArch. Pharm. Res.34(12)2141-2147(2011) 2.Jeong, H.U., Kwon, S.S., Kong, T.Y., et al.Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomesJ. Toxicol. Environ. Health A.77(22-24)1522-1532(2014) 3.Kim, C.-H., Lee, T., Oh, I., et al.Mast cell stabilizing effect of (-)-Elema-1,3,11(13)-trien-12-ol and thujopsene from Thujopsis dolabrata is mediated by down-regulation of interleukin-4 secretion in antigen-induced RBL-2H3 cellsBiol. Pharm. Bull.36(3)339-345(2013) 4.Bordoloi, M., Saikia, S., Kolita, B., et al.Volatile inhibitors of phosphatidylinositol-3-kinase (PI3K) pathway: Anticancer potential of aroma compounds of plant essential oilsAnticancer Agents Med. Chem.18(1)87-109(2018) 5.Kim, J.-R., Perumalsamy, H., Kwon, M.J., et al.Toxicity of hiba oil constituents and spray formulations to American house dust mites and copra mitesPest Manag. Sci.71(5)737-743(2015)
| Cas No. | 470-40-6 | SDF | |
| Synonyms | NSC 44707, cis-(-)-Thujopsene | ||
| Canonical SMILES | C[C@@]12[C@]3(C(C)(CCC2)C)[C@@](C(C)=CC1)([H])C3 | ||
| Formula | C15H24 | M.Wt | 204.4 |
| Solubility | Chloroform: slightly soluble,Dichloromethane: slightly soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.8924 mL | 24.4618 mL | 48.9237 mL |
| 5 mM | 0.9785 mL | 4.8924 mL | 9.7847 mL |
| 10 mM | 0.4892 mL | 2.4462 mL | 4.8924 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >85.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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