Thymidine (Synonyms: 2’-deoxy Thymidine,2’-deoxy-5-methyl-Uridine,5-Methyldeoxyuridine,NSC 21548,Thymine deoxyriboside) |
Catalog No.GC15815 |
pyrimidine nucleoside
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 50-89-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Thymidine, also named as deoxythymidine, deoxyribosylthymine and thymine deoxyriboside, is a pyrimidine deoxynucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. Thymidine is the DNA nucleoside T paired with deoxyadenosine (A) in DNA double helix. In cell biology it has been used to synchronize the cells in G1/early S phase. Thymidine occurs almost exclusively in DNA but it also occurs in the T-loop of tRNA. Thymidine is non-toxic and as part of one of the four nucleosides in DNA it is a naturally occurring compound existed in organisms and DNA viruses [1]. Thymidine is a nucleoside composed of a pentose sugar, deoxyribose, and a pyrimidine base thymine. Phosphorylation of thymidine with one, two or three phosphoric acid groups, can form dTMP (deoxythymidine monophosphate), dTDP, or dTTP. The molecular weight of thymidine is 242.229 u. The melting point is 185°C.
Reference:
[1] Meng S, Maragakis P, Papaloukas C, et al. DNA nucleoside interaction and identification with carbon nanotubes[J]. nano letters, 2007, 7(1): 45-50.
Cas No. | 50-89-5 | SDF | |
Synonyms | 2’-deoxy Thymidine,2’-deoxy-5-methyl-Uridine,5-Methyldeoxyuridine,NSC 21548,Thymine deoxyriboside | ||
Chemical Name | (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one | ||
Canonical SMILES | CC1=CN([C@@H]2O[C@H](CO)[C@@H](O)C2)C(NC1=O)=O | ||
Formula | C10H14N2O5 | M.Wt | 242.2 |
Solubility | ≥ 24.2mg/mL in DMSO with gentle warming, ≥ 53.6 mg/mL in Water, ≥ 3.75 mg/mL in EtOH with ultrasonic | Storage | Store at 0-6°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 4.1288 mL | 20.6441 mL | 41.2882 mL |
5 mM | 0.8258 mL | 4.1288 mL | 8.2576 mL |
10 mM | 0.4129 mL | 2.0644 mL | 4.1288 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 27 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *