Trioxsalen (Synonyms: NSC 71047,4,5’,8-Trimethylpsoralen,Trisoralen) |
Catalog No.GC15043
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intercalates into DNA and forms DNA single-strand adducts and interstrand crosslinks when activated with ultraviolet light
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3902-71-4
Sample solution is provided at 25 µL, 10mM.
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Trioxsalen has been reported to intercalate into DNA forming DNA single-strand adducts and interstrand crosslinks when activated with UV light.
In vitro: Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death unless repaired by cellular mechanisms. In research it can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage [1].
In vivo: Mice received 3H-trioxsalen either orally or intraperitoneally. It was found that over 88% of trioxsalen, after po or i.p. administration, was excreted in the urine within 8 hours and over 90% within 12 hours. The distribution patterns of trioxsalen radioactivity demonstrated that trioxsalen was selectively present in liver, skin, and blood and was barely detectable in other organs. The highest values were observed between 2 and 6 hours and diminished rapidly thereafter [1].
Clinical trial: In men receiving 40 mg unlabelled trioxsalen, 80% of the administered dose was excreted in urine within 8 hours as hydroxylated or glucuronide derivatives. It was also reported that trioxsalen transformed to a principal metabolite 5'-carboxy-4,8-dimethylpsoralen, which was found to be inactive as skin photosensitizer and to this transformation had been attributed the difference in the photoreactivity of trioxsalen when topically applied or systematically administered [1].
Reference:
[1] Mahmoud M. A. Hassan. Trioxsalen. Analytical Profiles of Drug Substances Volume 10, 1981, Pages 705-727.
| Cas No. | 3902-71-4 | SDF | |
| Synonyms | NSC 71047,4,5’,8-Trimethylpsoralen,Trisoralen | ||
| Chemical Name | 2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one | ||
| Canonical SMILES | CC1=CC2=CC(C(C)=C3)=C(C(C)=C2O1)OC3=O | ||
| Formula | C14H12O3 | M.Wt | 228.2 |
| Solubility | Soluble in dichloromethane | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.3821 mL | 21.9106 mL | 43.8212 mL |
| 5 mM | 876.4 μL | 4.3821 mL | 8.7642 mL |
| 10 mM | 438.2 μL | 2.1911 mL | 4.3821 mL |
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μL
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)