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U-51605

Catalog No.GC45104

U-51605 Chemical Structure

Size Price Stock Qty
100μg
$51.00
In stock
500μg
$231.00
In stock
1mg
$411.00
In stock
5mg Please Inquire Please Inquire

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Sample solution is provided at 25 µL, 10mM.

Quality Control

Quality Control & SDS

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Background

U-51605 is a stable analog of the endoperoxide prostaglandin H2 (PGH2). It is an inhibitor of both prostacyclin (PGI) and thromboxane (TX) synthases with more selectivity towards PGI synthase. U-51605 is also a partial agonist at TP receptors. In human foreskin fibroblasts, U-51605 inhibits PGI synthase at a concentration of 2.8 µM, whereas, human platelet TX synthase is inhibited at a concentration of 5.6 µM. At concentrations up to 1 µM, U-51605 reduced the release of prostacyclin in SHR aorta elicited by the calcium ionophore A-23187 with no effect on TXA2 production and yet significantly increased PGE2 and PGF2α release.

Chemical Properties

Cas No. 64192-56-9 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES CCCCCC/C=C/[C@H]1C2N=NC(C2)[C@@H]1C/C=C\CCCC(O)=O
Formula C20H32N2O2 M.Wt 332.5
Solubility DMF: >100 mg/ml (from U-46619),DMSO: >100 mg/ml (from U-46619),Ethanol: >100 mg/ml (from U-46619),PBS pH 7.2: >2 mg/ml (from U-46619) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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