Wee1 Inhibitor |
| Catalog No.GC49430 |
Wee1 Inhibitor is a potent checkpoint Wee1 kinase inhibitor with an IC50 of 0.011 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 622855-37-2
Sample solution is provided at 25 µL, 10mM.
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Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 µM for the E. coli enzyme).2
1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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