LAS-31180 |
| Catalog No.GC32529 |
LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137338-43-3
Sample solution is provided at 25 µL, 10mM.
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LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].
In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].
[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.
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