10-Formyltetrahydrofolate (sodium salt) (technical grade) (Synonyms: 10-CHO-FH4, 10-CHO-THF, N10-Formyltetrahydrofolate, 10-formyl H4PteGlu, 10-fTHF) |
| Catalog No.GC49872 |
10-Formyltetrahydrofolate (sodium salt) (technical grade) is a form of tetrahydrofolic acid that acts as a donor of formyl groups in anabolism.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 914800-65-0
Sample solution is provided at 25 µL, 10mM.
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10-Formyltetrahydrofolate is a formyl donor and cofactor, as well as a metabolite of 5,10-methylenetetrahydrofolic acid .1 It is formed from 5,10-methylenetetrahydrofolic acid by methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in the cytosol and MTHFD2 and MTHFD2L in the mitochondria. 10-Formyltetrahydrofolate provides the formyl group for conjugation to methionine-tRNA, which is required for mitochondrial protein translation initiation, and is also involved in purine biosynthesis.2,3
1.Li, A.M., and Ye, J.Reprogramming of serine, glycine and one-carbon metabolism in cancerBiochim. Biophys. Acta Mol. Basis Dis.1866(10)165841(2020) 2.Minton, D.R., Nam, M., McLaughlin, D.J., et al.Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAsMol. Cell69(4)610-621(2018) 3.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide biosynthesisBiochemistry(2002)
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