4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (Synonyms: 4-MU β-D-galactopyranoside-6-sulfate, 4-Methylumbelliferyl Gal-6S, 4-MU-Gal-6S) |
| Catalog No.GC42445 |
4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) is a fluorescent dye.
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Cas No.: 206443-06-3
Sample solution is provided at 25 µL, 10mM.
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4-Methylumbelliferyl β-D-Galactopyranoside-6-sulfate (sodium salt) (4-MU-Gal-6S) is a fluorogenic substrate used to quantify N-acetylgalactosamine-6-sulphatase (GALNS) activity. 4-MU-Gal-6S is cleaved by GALNS to release the fluorescent moiety 4-MU. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. It has been used to detect Morquio disease type A, a lysosomal storage disorder in which GALNS is deficient. 4-MU-Gal-6S can be used to assess GALNS activity in a very small blood volume to determine the extent of deficiency.
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