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5-HT2 antagonist 1 Catalog No.GC32655

Size Price Stock Qty
1mg
$1,324.00
In stock
5mg
$2,979.00
In stock
10mg
$5,066.00
In stock
20mg
$8,935.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 191592-09-3 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C1N(CCCN2CCN(C3=CC=C(F)C=C3)CC2)CCC(O)C4=C1C=CN4C
Formula C22H29FN4O2 M.Wt 400.49
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.

5-HT2 antagonist 1 shows 45%, 88%, 93% inhibition of 10 μM erotonin-induced contraction at 10 nM, 100 nM, 1000 nM, respectively, in guinea pig mesentcric artery. 5-HT2 antagonist 1 causes 1% and 10% inhibition of 10 μM norepinephrine-induced contraction at 10 and 100 nM, respectively, in guinea pig aorta[1].

[1]. Mizuno A, et al. Synthesis and serotonin 2 (5-HT2) receptor antagonist activity of 5-aminoalkyl-substituted pyrrolo[3,2-c]azepines and related compounds. Chem Pharm Bull (Tokyo). 2000 May;48(5):623-35.