Cytochalasin B (Phomin) (Synonyms: NSC 107658, Phomin) |
| Catalog No.GC32890 |
Cytochalasin B is a cyto-permeable mycotoxin, and it is isolated from an ascomycete fungus belonging to the Phoma genus[1-2].
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Cas No.: 14930-96-2
Sample solution is provided at 25 µL, 10mM.
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Cytochalasin B is a cyto-permeable mycotoxin, and it is isolated from an ascomycete fungus belonging to the Phoma genus[1-2]. Cytochalasin B is able to inhibit the formation of actin microfilaments through a direct effect on the polymerization of the cytoskeletal protein. By binding the fast-growing end of F-actin and interacting with capping proteins, influences the nucleation-elongation of actin microfilaments[3-4].
Cytochalasin B (0.1-10 µM; 0-72 h) influenced the metabolism, proliferation, and morphology of hASCs in a dose-dependent manner, in association with progressive disorganization of actin microfilaments[5]. Cytochalasin B is capable of inducing DNA fragmentation in a number of cells lines[6]. Cytochalasin B (10-8-10-1M; 24-96 h) effectively inhibited U251 cell proliferation in a dose- and time-dependent manner. Cytochalasin B increased the proportion of cells in the G2/M phase in a dose-dependent manner, thus increasing the mitotic index and decreasing CDC2 and cyclin B1 protein levels[7].
Cytochalasin B(Cytochalasins B was prepared in suspension form in 2% carboxymethyl cellulose 1% tween 20 (CMC/Tw); i.p.;10, 25, or 50 mg/kg; 8days ) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias[8].Cytochalasin B(5 µg/ml Cytochalasin B; 30 min) treatment of mouse oocytes during intracytoplasmic sperm injection (ICSI) increases embryo survival without impairment of development[9].
References:
[1]. Van Goietsenoven G, Mathieu V, et,al. In vitro growth inhibitory effects of cytochalasins and derivatives in cancer cells. Planta Med. 2011 May;77(7):711-7. doi: 10.1055/s-0030-1250523. Epub 2010 Nov 5. PMID: 21058241.
[2]. Trendowski M. Using cytochalasins to improve current chemotherapeutic approaches. Anticancer Agents Med Chem. 2015;15(3):327-35. doi: 10.2174/1871520614666141016164335. PMID: 25322987; PMCID: PMC4485394.
[3]. MacLean-Fletcher S, Pollard TD. Mechanism of action of cytochalasin B on actin. Cell. 1980 Jun;20(2):329-41. doi: 10.1016/0092-8674(80)90619-4. PMID: 6893016.
[4]. Flanagan MD, Lin S. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8. PMID: 7356663.
[5]. Bianconi E, Tassinari R, et,al. Cytochalasin B Modulates Nanomechanical Patterning and Fate in Human Adipose-Derived Stem Cells. Cells. 2022 May 12;11(10):1629. doi: 10.3390/cells11101629. PMID: 35626666; PMCID: PMC9139657.
[6]. Kolber MA, Broschat KO, et,al. Cytochalasin B induces cellular DNA fragmentation. FASEB J. 1990 Sep;4(12):3021-7. doi: 10.1096/fasebj.4.12.2394319. PMID: 2394319.
[7]. Tong ZG, Liu N, et,al. Cytochalasin B inhibits the proliferation of human glioma U251 cells through cell cycle arrest and apoptosis. Genet Mol Res. 2014 Dec 19;13(4):10811-22. doi: 10.4238/2014.December.19.2. PMID: 25526201.
[8]. Trendowski M, Mitchell JM, et,al. Chemotherapy with cytochalasin congeners in vitro and in vivo against murine models. Invest New Drugs. 2015 Apr;33(2):290-9. doi: 10.1007/s10637-014-0203-5. Epub 2015 Jan 7. PMID: 25563824; PMCID: PMC4387261.
[9].Hu LL, Shen XH, et,al. Cytochalasin B treatment of mouse oocytes during intracytoplasmic sperm injection (ICSI) increases embryo survival without impairment of development. Zygote. 2012 Nov;20(4):361-9. doi: 10.1017/S0967199411000438. Epub 2011 Aug 15. PMID: 21838963.
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