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Alprenolol ((RS)-Alprenolol) (Synonyms: (±)-Alprenolol, dl-Alprenolol, (RS)-Alprenolol)

Catalog No.GC32905

Alprenolol ((RS)-Alprenolol) ((RS)-Alprenolol ((RS)-Alprenolol); dl-Alprenolol ((RS)-Alprenolol)) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol ((RS)-Alprenolol) is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent.

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Alprenolol ((RS)-Alprenolol) Chemical Structure

Cas No.: 13655-52-2

Size Price Stock Qty
10mM (in 1mL DMSO)
$67.00
In stock
50mg
$61.00
In stock
100mg
$101.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist.The reference for administration is 10 mg/kg.

[1]. Schreiber R et al. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):211-5. [2]. Millan MJ et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther, 1994 Jan, 2

Chemical Properties

Cas No. 13655-52-2 SDF
Synonyms (±)-Alprenolol, dl-Alprenolol, (RS)-Alprenolol
Canonical SMILES OC(COC1=CC=CC=C1CC=C)CNC(C)C
Formula C15H23NO2 M.Wt 249.35
Solubility DMSO : ≥ 100 mg/mL (401.04 mM);Water : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.0104 mL 20.0521 mL 40.1043 mL
5 mM 0.8021 mL 4.0104 mL 8.0209 mL
10 mM 0.401 mL 2.0052 mL 4.0104 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 5 reference(s) in Google Scholar.)

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