AZ Dyrk1B 33 |
| Catalog No.GC50221 |
Potent and selective Dyrk1B kinase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1679330-37-0
Sample solution is provided at 25 µL, 10mM.
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Potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 ; displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).
Kettle et al (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 58 2834 PMID:25738750
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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