Bongkrekic Acid (Synonyms: Bongkrek Acid) |
| Catalog No.GC42965 |
An inhibitor of mitochondrial adenine nucleotide translocase
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 11076-19-0
Sample solution is provided at 25 µL, 10mM.
Bongkrekic acid is a natural toxin first isolated from coconut tempeh contaminated with bacteria. It is a polyunsaturated long-chain fatty acid derivative that acts as a potent inhibitor of the mitochondrial adenine nucleotide (ADP/ATP) translocase (Ki < 2 nM). [1][2][3]Despite its high affinity, bongkrekic acid has a slow rate of action in intact preparations, as it must permeate the inner mitochondrial membrane to bind the translocase.[3]
Reference:
[1]. Henderson, P.J.F., and Lardy, H.A. Bongkrekic acid. An inhibitor of the adenine nucleotide translocase of mitochondria. The Journal of Biological Chemisty 245(6), 1319-1326 (1970).
[2]. Dahout-Gonzalez, C., Hury, H., Trézéguet, V., et al. Molecular, functional, and pathological aspects of the mitochondrial ADP/ATP carrier. Physiology (Bethesda) 21, 242-249 (2006).
[3]. Klingenberg, M. The ADP and ATP transport in mitochondria and its carrier. Biochimica et Biophysica Acta 1778(10), 1978-2021 (2008).
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *