CAY10638 (Synonyms: Thiazolidinedione derivative) |
| Catalog No.GC18893 |
Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.
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Cas No.: 1221413-57-5
Sample solution is provided at 25 µL, 10mM.
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Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity. Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity. CAY10638 is a TZD derivative that inhibits 15-PGDH activity with an IC50 value of 31 nM.
Review for CAY10638
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
Review for CAY10638
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