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D159687 Catalog No.GC34895

Size Price Stock Qty
10mM*1mL in DMSO
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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 1155877-97-6 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES NC(NC1=CC=C(CC2=CC(C3=CC(Cl)=CC=C3)=C(OC)C=C2)C=C1)=O
Formula C21H19ClN2O2 M.Wt 366.84
Solubility DMSO : 150 mg/mL (408.90 mM; Need ultrasonic) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).



D159687 is a selective PDE4D inhibitor[1]. PDE4D[1]

D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line)

D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4-6 year old) [2]

[1]. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115.