|D159687 Catalog No.GC34895|
Sample solution is provided at 25 µL, 10mM.
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|Cas No.||1155877-97-6||SDF||Download SDF|
|Solubility||DMSO : 150 mg/mL (408.90 mM; Need ultrasonic)||Storage||Store at -20°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
D159687 is a selective PDE4D inhibitor. PDE4D
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM. Western Blot Analysis Cell Line: HT-22 (mouse hippocampal cell line)
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques. Animal Model: Female Cynomolgus macaques (4-6 year old) 
. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115.