D159687 |
| Catalog No.GC34895 |
D159687 is a selective PDE4D inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1155877-97-6
Sample solution is provided at 25 µL, 10mM.
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D159687 is a selective PDE4D inhibitor[1]. PDE4D[1]
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1]. Western Blot Analysis[1] Cell Line: HT-22 (mouse hippocampal cell line)
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2]. Animal Model: Female Cynomolgus macaques (4-6 year old) [2]
[1]. Zhang C, et al. Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Sci Rep. 2017 Jan 5;7:40115.
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