Diminutol (Synonyms: NG72) |
| Catalog No.GC43469 |
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis.
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Cas No.: 361431-33-6
Sample solution is provided at 25 µL, 10mM.
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Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 µM), to destabilize microtubules and disrupt mitosis. At 50 µM, it directly affects tubulin polymerization in Xenopus egg extracts without interfering with the activity of Cdk1, DNA replication, or actin polymerization.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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