Diosmetin-d3 (Synonyms: Diosmetol-d3, Luteolin 4'-methyl ester-d3) |
| Catalog No.GC47234 |
An internal standard for the quantification of diosmetin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1189728-54-8
Sample solution is provided at 25 µL, 10mM.
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Diosmetin-d3 is intended for use as an internal standard for the quantification of diosmetin by GC- or LC-MS. Diosmetin is a flavonoid that has been found in citrus fruits and has diverse biological activities.1,2,3,4 It inhibits the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1 (Kis = 89 and 16 nM, respectively).1 Diosmetin prevents increases in erythrocyte reactive oxygen species (ROS) and malondialdehyde (MDA) levels induced by AAPH in a concentration-dependent manner.2 It reduces tumor growth and tumor blood vessel density in a B16/F10 murine melanoma model when administered at a dose of 1 mg/kg twice per day.3 Diosmetin (0.5 mg/kg) inhibits lung goblet cell hyperplasia and collagen deposition and decreases the number of eosinophils and neutrophils in bronchoalveolar lavage fluid (BALF) in a mouse model of chronic asthma induced by ovalbumin.4
1.Androutsopoulos, V.P., Papakyriakou, A., Vourloumis, D., et al.Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoidsBioorg. Med. Chem.19(9)2842-2849(2011) 2.Liao, W., Ning, Z., Chen, L., et al.Intracellular antioxidant detoxifying effects of diosmetin on 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress through inhibition of reactive oxygen species generationJ. Agric. Food Chem.62(34)8648-8654(2014) 3.Choi, J., Lee, D.H., Park, S.Y., et al.Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancerBiomed. Pharmacother.117109091(2019) 4.Ge, A., Liu, Y., Zeng, X., et al.Effect of diosmetin on airway remodeling in a murine model of chronic asthmaActa Biochim. Biophys. Sin. (Shanghai)47(8)604-611(2015)
| Cas No. | 1189728-54-8 | SDF | |
| Synonyms | Diosmetol-d3, Luteolin 4'-methyl ester-d3 | ||
| Canonical SMILES | O=C1C=C(C2=CC=C(OC([2H])([2H])[2H])C(O)=C2)OC3=CC(O)=CC(O)=C31 | ||
| Formula | C16H9D3O6 | M.Wt | 303.3 |
| Solubility | DMSO: slightly soluble,Methanol: slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2971 mL | 16.4853 mL | 32.9707 mL |
| 5 mM | 0.6594 mL | 3.2971 mL | 6.5941 mL |
| 10 mM | 0.3297 mL | 1.6485 mL | 3.2971 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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