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Enterostatin

Catalog No.GC18105

Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.

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Enterostatin Chemical Structure

Cas No.: 117830-79-2

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1mg
$62.00
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5mg
$139.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Enterostatin, human, mouse, rat is a pentapeptide that reduces fat intake.

In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%)[1].

Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion[2]. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice[3]. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake[4].

References:
[1]. Silvestre RA, et al. Effect of enterostatin on insulin, glucagon, and somatostatin secretion in the perfused rat pancreas. Diabetes. 1996 Sep;45(9):1157-60.
[2]. Erlanson-Albertsson C, et al. Enterostatin--a peptide regulating fat intake. Obes Res. 1997 Jul;5(4):360-72.
[3]. Ohinata K, et al. Enterostatin (APGPR) enhances memory consolidation in mice. Peptides. 2007 Mar;28(3):719-21.
[4]. Sörhede M, et al. Enterostatin: a gut-brain peptide regulating fat intake in rat. J Physiol Paris. 1993;87(4):273-5.

Chemical Properties

Cas No. 117830-79-2 SDF
Chemical Name (S)-2-((S)-1-(2-((S)-1-((S)-2-aminopropanoyl)pyrrolidine-2-carboxamido)acetyl)pyrrolidine-2-carboxamido)-5-((diaminomethylene)amino)pentanoic acid
Canonical SMILES O=C([C@H]1N(C([C@H](C)N)=O)CCC1)NCC(N2[C@H](C(N[C@H](C(O)=O)CCC/N=C(N)/N)=O)CCC2)=O
Formula C21H36N8O6 M.Wt 496.57
Solubility Soluble to 0.70 mg/ml in sterile water Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.0138 mL 10.0691 mL 20.1381 mL
5 mM 0.4028 mL 2.0138 mL 4.0276 mL
10 mM 0.2014 mL 1.0069 mL 2.0138 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 27 reference(s) in Google Scholar.)

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