EX-527 R-enantiomer (Synonyms: (R)-EX-527) |
| Catalog No.GC17126 |
EX-527 R-enantiomer ((R)-EX-527) is a R-enantiomer of Selisistat. Selisistat (EX-527) is a potent and selective SIRT1 inhibitor with IC50 of 98 nM.
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Cas No.: 848193-69-1
Sample solution is provided at 25 µL, 10mM.
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Selisistat R-enantiomer (EX-527 R-enantiomer) is much less active R-enantiomer of Selisistat, with an IC50 of > 100 μM for SIRT1.
References:
[1]. Napper AD, et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54.
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