Ferulenol |
Catalog No.GC12319
One-Click Copy Product Info
|
antimycobacterial activity and stimulates tubulin polymerization
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6805-34-1
Sample solution is provided at 25 µL, 10mM.
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Ferulenol is a prenylated 4-hydroxycoumarin derivative from Ferula communis var. genuine with haemorrhagic action [1]. It has been demonstrated that ferulenol exihibits potent antimycobacterial activity [2].
In vitro: Ferulenol stimulated tubulin polymerization in the absence of GTP, with a less extensive polymerization profile at 100 pM concentration. Ferulenol decreased radiolabeled colchicine bound by tubulin in a dose-dependent manner. Ferulenol altered the normal nuclear morphology of MCF-7 cells. Treatment with ferulenol (100 nM and 1 μM) for 24h induced a dose-dependent reduction of cell viability [3]
In vivo: In albino mice, the acute LD50s of ferulenol by single po or ip were 2,100 and 319 mg/kg bw, respectively. Three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages. Male mice were more sensitive to intoxication than females [4].
References:
[1] Lamnaouer D, Bodo B, Martin M T, et al. Ferulenol and ω-hydroxyferulenol, toxic coumarins from Ferula communis var. genuina[J]. Phytochemistry, 1987, 26(6): 1613-1615.
[2] E. Mamoci, I. Cavoski, V. Simone, et al. Chemical composition and in vitro activity of plant extracts from Ferula communis and Dittrichia viscosa against postharvest fungi. Molecules 16(3), 2609-2625 (2011).
[3] Bocca C, Gabriel L, Bozzo F, et al. Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol[J]. Planta medica, 2002, 68(12): 1135-1137.
[4] Fraigui O, Lamnaouer D, Faouzi M Y. Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L[J]. Veterinary and human toxicology, 2002, 44(1): 5-7.
| Cas No. | 6805-34-1 | SDF | |
| Chemical Name | 4-hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-2H-1-benzopyran-2-one | ||
| Canonical SMILES | O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=C(O)C2=CC=CC=C2O1 | ||
| Formula | C24H30O3 | M.Wt | 366.5 |
| Solubility | DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7285 mL | 13.6426 mL | 27.2851 mL |
| 5 mM | 545.7 μL | 2.7285 mL | 5.457 mL |
| 10 mM | 272.9 μL | 1.3643 mL | 2.7285 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)