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CAY10606

Catalog No.GC18877 Copy One-Click Copy Product Info

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations.

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CAY10606 Chemical Structure

Cas No.: 1159576-98-3

Size Price Stock Qty
1mg
$85.00
In stock
5mg
$381.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of CAY10606

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.

Chemical Properties of CAY10606

Cas No. 1159576-98-3 SDF
Chemical Name 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester
Canonical SMILES OC1=CC2=C(NC(CC3=CC=CC(Cl)=C3)=C2C(OCC)=O)C4=C1C=CC=C4
Formula C22H18ClNO3 M.Wt 379.8
Solubility DMF: 25 mg/ml,DMSO: 25 mg/ml,Ethanol: 20 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of CAY10606

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1 mg 5 mg 10 mg
1 mM 2.633 mL 13.1648 mL 26.3296 mL
5 mM 526.6 μL 2.633 mL 5.2659 mL
10 mM 263.3 μL 1.3165 mL 2.633 mL
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In vivo Formulation Calculator (Clear solution) of CAY10606

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for CAY10606

Average Rating: 5 ★★★★★ (Based on Reviews and 5 reference(s) in Google Scholar.)

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