Home>>FFN-102 (trifluoroacetate salt)
FFN-102 (trifluoroacetate salt) Catalog No.GC18579

A fluorescent probe to label dopaminergic cells

Size Price Stock Qty
1mg
$32.00
In stock
5mg
$129.00
In stock
10mg
$241.00
In stock
25mg
$514.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 1234064-11-9 SDF Download SDF
Synonyms N/A
Chemical Name 4-(2-aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one 2,2,2-trifluoroacetate
Canonical SMILES OC1=C(Cl)C=C(C(CCN)=CC(O2)=O)C2=C1.FC(F)(C(O)=O)F
Formula C11H10ClNO3.CF3COOH M.Wt 353.7
Solubility DMF: 20 mg/ml,DMSO: 20 mg/ml Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 uM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 uM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 uM.