FGIN-1-27 |
| Catalog No.GC14017 |
high affinity agonist of the translocator protein (TSPO,peripheral benzodiazepine receptor)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 142720-24-9
Sample solution is provided at 25 µL, 10mM.
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FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1]
Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006).
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