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Proteases

Proteases - Signaling Pathways | GlpBio

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Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Research Areas

Products Related to Proteases(4761)

  • GC91598 structure
    GC91598GPX4 16
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    Purity: >98.00%

    GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).

  • GC91613 structure
    GC91613FerroLOXIN-1
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    Purity: >90.00%

    FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

  • GC91623 structure
    GC91623Ferroptosis Inducer 24
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    Purity: >95.00%

    Ferroptosis inducer 24 is an inducer of ferroptosis.

  • GC91688 structure
    GC91688PDIC-NN
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    Purity: >95.00%

    PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.

  • GC91782 structure
    GC91782DPP-9 Inhibitor 42
    Purity: >95.00%

    DPP-9 inhibitor 42 is an inhibitor of dipeptidyl peptidase 9 (DDP-9; IC50 = 0.0034 µM).

  • GC91800 structure
    GC91800CPPA-TPP
    Purity: >75.00%

    CPPA-TPP is a chain transfer agent conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP).

  • GC91820 structure
    GC91820PDIC-NS
    Purity: >95.00%

    PDIC-NS is an activator of stimulator of interferon genes (STING).

  • GC92031 structure
    GC92031GPX4 Inhibitor 17
    Purity: >98.00%

    GPX4 Inhibitor 17 est un inhibiteur contenant du ferrocène de la glutathion peroxydase 4 (GPX4) et un inducteur de la ferroptose.

  • GC92061 structure
    GC920611-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
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    Purity: >95.00%

    1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC sont des Phospholipides oxydés contenant de l'acide palmitique et du 13s - hode aux positions Sn - 1 et Sn - 2, respectivement.

  • GD09670 structure
    GD096703,3-Dimethyl-1-butanol
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    Purity: >99.50%

    3,3-Dimethyl-1-butanol est un inhibiteur oral qui réduit la production de triméthylamine (TMA) par les micro-organismes en supprimant l'activité de différentes TMA lyases microbiennes.

  • GD13954 structure
    GD13954Gentisuric Acid
    CAS: 25351-24-0
    Purity: >98.00%

    Gentisuric Acid a la formule moléculaire C₉H₉NO₅, un poids moléculaire de 211.17, et son nom chimique est N-(2,5-dihydroxybenzoyl) glycine. Gentisuric acid est un métabolite de l'acide salicylique ou de l'aspirine et sert de substrat pour α-amidomonooxygénase (PAM), Gentisuric acid possède la capacité d'atténuer les lésions à DNA induits par la mitomycine C.

  • GD20392 structure
    GD20392Potassium Hyaluronate from Cockscomb
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    Purity: >98.00%

    Potassium Hyaluronate from Cockscomb est une macromolécule constitués d'unités disaccharidiques répétées. Il est utilisé comme agent de soin pour la peau en cosmétique et peut pénétrer dans le derme.

  • GD23102 structure
    GD23102γ-Tocotrienol
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    Purity: >98.00%

    γ-Tocotrienol (γ-T3) est un sous-type de tocotriénol et un type majeur de vitamine E avec 2 groupes méthyles substitués.

  • GF05704 structure
    GF05704Neochlorogenic acid methyl ester
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    Purity: >98.00%

    Neochlorogenic acid methyl ester est un composé avec une activité anti-HBV.

  • GF14666 structure
    GF14666D-Glucosamine 6-phosphate
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    Purity: >98.00%

    Le D-Glucosamine 6-phosphate est un métabolite endogène, une forme phosphorylée de la glucosamine, synthétisé par la glutamine fructose-6-phosphate aminotransférase (GFAT).

  • GF20672 structure
    GF206725α-Androstanedione
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    Purity: >98.00%

    5α-Androstanedione est un métabolite hormonal stéroïdien endogène, un intermédiaire essentiel.

  • GN10040 structure
    GN10040Dehydrocorydaline
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    Purity: >98.00%

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  • GN10055 structure
    GN10055Mulberroside A
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    Purity: >98.00%
  • GN10062 structure
    GN100625-HTP
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    Purity: >99.50%
  • GN10063 structure
    GN10063Arctigenin
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    Purity: >99.50%

    Arctigenin, un composé ligane naturel, a démontré les activités anti-cancéreuses dans le cancer. Arctigenin exhibe les activités antioxydantes, anti-inflammatoires et antivirales (virus de l'influenza A).

  • GN10072 structure
    GN10072Daidzin
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    Purity: >99.50%
  • GN10073 structure
    GN10073Arbutin
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    Purity: >99.50%
  • GN10091 structure
    GN10091Schaftoside
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    Purity: >99.50%
  • GN10146 structure
    GN10146Butane diacid
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    Purity: >98.00%