BI-0252 |
| Catalog No.GC35511 |
BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1818291-27-8
Sample solution is provided at 25 µL, 10mM.
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BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis[1]. IC50: 4 nM (MDM2-p53)[1]
[1]. Gollner A, et al. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J Med Chem. 2016 Nov 23;59(22):10147-10162.
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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