Home>>Signaling Pathways>> PROTAC>> E3 Ligase Ligand-Linker Conjugate>>E3 ligase Ligand-Linker Conjugates 46

E3 ligase Ligand-Linker Conjugates 46

Catalog No.GC35953

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E3 ligase Ligand-Linker Conjugates 46 Chemical Structure

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

E3 ligase Ligand-Linker Conjugates 46 incorporates a cIAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 46 can be used to design PROTAC degrader[1]. cIAP1

[1]. Itoh Y, et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg Med Chem. 2011 Nov 15;19(22):6768-78.

Chemical Properties

Cas No. SDF
Canonical SMILES NCCOCCOCCOCCNC([C@H](NC([C@H](O)[C@@H](NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)CC4=CC=CC=C4)=O)CC(C)C)=O
Formula C39H52N4O8 M.Wt 704.85
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.4187 mL 7.0937 mL 14.1874 mL
5 mM 0.2837 mL 1.4187 mL 2.8375 mL
10 mM 0.1419 mL 0.7094 mL 1.4187 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for E3 ligase Ligand-Linker Conjugates 46

Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

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