(±)-Ketoprofen-d3 (Synonyms: (R,S)-Ketoprofen-d3, 2-(3-benzoylphenyl)Propionic Acid-d3) |
| Catalog No.GC45278 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 159490-55-8
Sample solution is provided at 25 µL, 10mM.
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(±)-Ketoprofen-d3 is intended for use as an internal standard for the quantification of (±)-ketoprofen by GC- or LC-MS. (±)-Ketoprofen is a non-selective COX inhibitor and non-steroidal anti-inflammatory drug (NSAID).1 It inhibits human recombinant COX-1 and COX-2 with IC50 values of 0.5 and 2.33 μM, respectively. In vivo, (±)-ketoprofen reduces carrageenan-induced paw edema and increases latency to paw withdrawal in the hot plate test in rats when administered using a sustained-release implant.2 Formulations containing (±)-ketoprofen have been used to treat pain and inflammation in osteoarthritis.
References
1. Barnett, J., Chow, J., Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochim Biophys. Acta. 1209(1), 130-139 (1994).
2. Zhang, J., Xu, X., Zhu, L., et al. Preparation and pre-clinical characterization of sustained release ketoprofen implants for the management of pain and inflammation in osteoarthritis. Trop. J. Pharm. Res. 17(4), 577-582 (2018).
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