Formoterol |
Catalog No.GF11341
One-Click Copy Product Info
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Formoterol is a kind of long-acting β2-adrenergic receptor (β2AR) agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 73573-87-2
Sample solution is provided at 25 µL, 10mM.
Formoterol is a kind of long-acting β2-adrenergic receptor (β2AR) agonist [1]. Formoterol is widely used for symptomatic relief in asthma and control of chronic obstructive pulmonary disease (COPD) [2]. The therapeutic mechanism of Formoterol involves both bronchodilation through airway smooth muscle relaxation and anti-inflammatory activity [2].
Formoterol (0.1μM; 24h) inhibited secretion of TNFα in the bronchial epithelial (BE) cells infected with rhinovirus [3]. Formoterol (1μM; 24h) effectively reduced tert-butyl hydroperoxide-induced SH-SY5Y cell death [1]. Formoterol (0.1nM~1μM; 24h) inhibited the IgE-dependent release of histamine from human lung mast cells in a concentration-dependent manner [4].
Formoterol (1mg/kg; 4 weeks; s.c.) decreased the expression of Fbxo32 and Trim63 in muscle wasting Balb/c mice induced by doxorubicin hydrochloride [5]. Formoterol (1mg/kg; 2 weeks; i.p.) prevented abdominal aortic aneurysm formation in erythropoietin-induced ApoE−/− mice [2].
References:
[1] Chang J C, Chang H S, Chao Y C, et al. Formoterol acting via β2-adrenoreceptor restores mitochondrial dysfunction caused by parkinson's disease-related UQCRC1 mutation and improves mitochondrial homeostasis including dynamic and transport [J]. Biology, 2024, 13(4): 231.
[2] Zhang J, Cao Y, Ren R, et al. Medium-dose formoterol attenuated abdominal aortic aneurysm induced by EPO via β2AR/cAMP/SIRT1 pathway [J]. Advanced science, 2024, 11(15): e2306232.
[3] Bochkov Y A, Busse W W, Brockman-Schneider R A, et al. Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses [J]. Respiratory research, 2013, 14(1): 98.
[4] Scola A M, Chong L K, Suvarna S K, et al. Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol [J]. British journal of pharmacology, 2004, 141(1): 163-171.
[5] De Lima Junior E A, Teixeira A A S, Silveira L S, et al. Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy [J]. Frontiers in oncology, 2023, 13: 1237709.
| Cell experiment [1]: | |
Cell lines | Bronchial epithelial (BE) cells |
Preparation Method | BE cells were obtained from airway brushings. Cells were incubated for 24h with Formoterol (0.01% DMSO drug vehicle), and then infected with 0.25 mL of rhinovirus-16 (5×106 plaque forming units [PFU]/mL). After 24h, cytokine secretion (TNFα) was analyzed. |
Reaction Conditions | 0.1μM; 24h |
Applications | Formoterol inhibited secretion of TNFα in the cells. |
| Animal experiment [2]: | |
Animal models | Male Balb/c mice |
Preparation Method | The mice received doxorubicin hydrochloride (DOX) to induce muscle wasting. One of the groups treated with Formoterol, and another not submitted to Formoterol treatment received saline solution (0.9%) by the corresponding route of administration. The mice were euthanized for sample collection after 4 weeks. |
Dosage form | 1mg/kg; 4 weeks; s.c. |
Applications | Formoterol protected against DOX-induced increase in Fbxo32 and Trim63 gene expression. |
References: | |
| Cas No. | 73573-87-2 | SDF | |
| Formula | C19H24N2O4 | M.Wt | 344.4 |
| Solubility | DMSO : 250 mg/mL (725.90 mM; Need ultrasonic) | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9036 mL | 14.518 mL | 29.036 mL |
| 5 mM | 580.7 μL | 2.9036 mL | 5.8072 mL |
| 10 mM | 290.4 μL | 1.4518 mL | 2.9036 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)