Formoterol
Catalog No.: GF11341Purity:>98.00%
Formoterol is a kind of long-acting β2-adrenergic receptor (β2AR) agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 73573-87-2
10mM (in 1mL DMSO)In Stock
$31.00
1
5mgIn Stock
$28.00
1
10mgIn Stock
$48.00
1
25mgIn Stock
$88.00
1
50mgIn Stock
$144.00
1
100mgIn Stock
$243.00
1
200mgIn Stock
$384.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $31.00 | In Stock | 1 | |
| 5mg | $28.00 | In Stock | 1 | |
| 10mg | $48.00 | In Stock | 1 | |
| 25mg | $88.00 | In Stock | 1 | |
| 50mg | $144.00 | In Stock | 1 | |
| 100mg | $243.00 | In Stock | 1 | |
| 200mg | $384.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citations
1 publicationsPublications from researchers using this productDescription
Formoterol is a kind of long-acting β2-adrenergic receptor (β2AR) agonist [1]. Formoterol is widely used for symptomatic relief in asthma and control of chronic obstructive pulmonary disease (COPD) [2]. The therapeutic mechanism of Formoterol involves both bronchodilation through airway smooth muscle relaxation and anti-inflammatory activity [2].
Formoterol (0.1μM; 24h) inhibited secretion of TNFα in the bronchial epithelial (BE) cells infected with rhinovirus [3]. Formoterol (1μM; 24h) effectively reduced tert-butyl hydroperoxide-induced SH-SY5Y cell death [1]. Formoterol (0.1nM~1μM; 24h) inhibited the IgE-dependent release of histamine from human lung mast cells in a concentration-dependent manner [4].
Formoterol (1mg/kg; 4 weeks; s.c.) decreased the expression of Fbxo32 and Trim63 in muscle wasting Balb/c mice induced by doxorubicin hydrochloride [5]. Formoterol (1mg/kg; 2 weeks; i.p.) prevented abdominal aortic aneurysm formation in erythropoietin-induced ApoE−/− mice [2].
References:
[1] Chang J C, Chang H S, Chao Y C, et al. Formoterol acting via β2-adrenoreceptor restores mitochondrial dysfunction caused by parkinson's disease-related UQCRC1 mutation and improves mitochondrial homeostasis including dynamic and transport [J]. Biology, 2024, 13(4): 231.
[2] Zhang J, Cao Y, Ren R, et al. Medium-dose formoterol attenuated abdominal aortic aneurysm induced by EPO via β2AR/cAMP/SIRT1 pathway [J]. Advanced science, 2024, 11(15): e2306232.
[3] Bochkov Y A, Busse W W, Brockman-Schneider R A, et al. Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses [J]. Respiratory research, 2013, 14(1): 98.
[4] Scola A M, Chong L K, Suvarna S K, et al. Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol [J]. British journal of pharmacology, 2004, 141(1): 163-171.
[5] De Lima Junior E A, Teixeira A A S, Silveira L S, et al. Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy [J]. Frontiers in oncology, 2023, 13: 1237709.
Protocol
| Cell experiment [1]: | |
Cell lines | Bronchial epithelial (BE) cells |
Preparation Method | BE cells were obtained from airway brushings. Cells were incubated for 24h with Formoterol (0.01% DMSO drug vehicle), and then infected with 0.25 mL of rhinovirus-16 (5×106 plaque forming units [PFU]/mL). After 24h, cytokine secretion (TNFα) was analyzed. |
Reaction Conditions | 0.1μM; 24h |
Applications | Formoterol inhibited secretion of TNFα in the cells. |
| Animal experiment [2]: | |
Animal models | Male Balb/c mice |
Preparation Method | The mice received doxorubicin hydrochloride (DOX) to induce muscle wasting. One of the groups treated with Formoterol, and another not submitted to Formoterol treatment received saline solution (0.9%) by the corresponding route of administration. The mice were euthanized for sample collection after 4 weeks. |
Dosage form | 1mg/kg; 4 weeks; s.c. |
Applications | Formoterol protected against DOX-induced increase in Fbxo32 and Trim63 gene expression. |
References: | |
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
73573-87-2
Molecular Formula
C19H24N2O4
Molecular Weight
344.4
Solubility
DMSO : 250 mg/mL (725.90 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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