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GR 159897 Catalog No.GC16408

neurokinin NK2 receptor antagonist,orally active

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10mg
$302.00
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50mg
$1,268.00
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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 158848-32-9 SDF
Chemical Name 5-fluoro-3-(2-(4-methoxy-4-((phenylsulfinyl)methyl)piperidin-1-yl)ethyl)-1H-indole
Canonical SMILES FC1=CC=C2NC=C(C2=C1)CCN3CCC(CC3)(CS(C4=CC=CC=C4)=O)OC
Formula C23H27FN2O2S M.Wt 414.54
Solubility <20.73mg/ml in DMSO; <4.15mg/ml in ethanol Storage Desiccate at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide antagonist at tachykinin NK2 receptors, inhibits binding of [3H]GR100679 to hNK2-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction, with anxiolytic-like activity[1].

References:
[1]. Beresford IJ, et al. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8.