Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> GPCR/G protein >> Neurokinin Receptor

Neurokinin Receptor

There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.

Targets for  Neurokinin Receptor

Products for  Neurokinin Receptor

  1. Cat.No. Product Name Information
  2. GC69805 (R)-Casopitant

    (R)-GW679769

    (R)-Casopitant ((R)-GW679769) is an isomer of Casopitant. Casopitant is an NK(1) receptor antagonist that can be used in the research of chemotherapy-induced nausea and vomiting.

     (R)-Casopitant Chemical Structure
  3. GC15200 Aprepitant

    Emend, L754,030, MK-869, ONO7436

     Aprepitant is a novel and highly selective Neurokinin-1 (NK-1) receptor antagonist. Aprepitant Chemical Structure
  4. GC33724 Befetupitant (Ro67-5930)

    Ro67-5930

     Befetupitant (Ro67-5930) is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist. Befetupitant (Ro67-5930) Chemical Structure
  5. GA20847 Biotinyl-Substance P Biotinyl-Substance P is the biotin tagged Substance P. Biotinyl-Substance P Chemical Structure
  6. GC62888 Casopitant mesylate

    GW679769B

     Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate Chemical Structure
  7. GC50042 CP 122721 hydrochloride High affinity NK1 antagonist CP 122721 hydrochloride Chemical Structure
  8. GC35751 CS-003 Free base CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base Chemical Structure
  9. GC62951 Elinzanetant

    NT-814; BAY3427080

     Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia. Elinzanetant Chemical Structure
  10. GC15591 Eprazinone 2HCl

    NSC 317935

     Eprazinone 2HCl is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone 2HCl Chemical Structure
  11. GC30104 Fezolinetant (ESN-364) Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes. Fezolinetant (ESN-364) Chemical Structure
  12. GC16246 Fosaprepitant Neurokinin-1 antagonist Fosaprepitant Chemical Structure
  13. GC10659 Fosaprepitant dimeglumine salt

    MK 0517

     Fosaprepitant dimeglumine salt (MK-0517) is a prodrug of Aprepitant. Fosaprepitant dimeglumine salt Chemical Structure
  14. GC64711 Fosnetupitant Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant Chemical Structure
  15. GC16408 GR 159897 neurokinin NK2 receptor antagonist,orally active GR 159897 Chemical Structure
  16. GC50069 GR 203040 Potent and selective NK1 antagonist GR 203040 Chemical Structure
  17. GC18080 GR 73632 Potent and selective tachykinin NK1 receptor agonist GR 73632 Chemical Structure
  18. GC13239 Hemokinin 1 (mouse)

    agonist at the tachykinin NK1 receptor

     Hemokinin 1 (mouse) Chemical Structure
  19. GC31199 Ibodutant (MEN 15596)

    MEN 15596

     Ibodutant (MEN 15596) (MEN 15596) is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1. Ibodutant (MEN 15596) Chemical Structure
  20. GC31145 Kassinin Kassinin is a peptide derived from the Kassina frog. Kassinin Chemical Structure
  21. GC72876 L-703606 oxalate hydrate L-703606 oxalate drate is a potent, selective antagonist of NK1 receptor. L-703606 oxalate hydrate Chemical Structure
  22. GC18128 L-732,138 tachykinin NK1 receptor antagonist L-732,138 Chemical Structure
  23. GC36543 Maropitant

    CJ-11,972

     Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant Chemical Structure
  24. GC25618 Maropitant citrate Maropitant citrate Chemical Structure
  25. GC71154 MEN 10207 MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 Chemical Structure
  26. GC17547 MEN 10376

    DYWVWWK-NH2, Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2

     NK2 receptor antagonist MEN 10376 Chemical Structure
  27. GC36582 Men 10376 TFA

    Neurokinin-2 receptor antagonist TFA

     Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. Men 10376 TFA Chemical Structure
  28. GC31300 MEN11467 MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK1 receptor antagonist. MEN11467 Chemical Structure
  29. GC34408 Monohydroxy Netupitant D6 Monohydroxy Netupitant D6 is the deuterium labeled Monohydroxy Netupitant, which is a metabolite of Netupitant. Monohydroxy Netupitant D6 Chemical Structure
  30. GC17596 Netupitant

    Ro 6731898/000

     neurokinin 1 (NK1) receptor antagonist Netupitant Chemical Structure
  31. GC34418 Netupitant D6 (CID-6451149 D6) Netupitant D6 (CID-6451149 D6) Chemical Structure
  32. GC33559 Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant) Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist. Netupitant metabolite Monohydroxy Netupitant (Monohydroxy Netupitant) Chemical Structure
  33. GC45824 Netupitant-d6 An internal standard for the quantification of netupitant Netupitant-d6 Chemical Structure
  34. GC11738 Neurokinin A (porcine) Neurokinin A (porcine) (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A (porcine) Chemical Structure
  35. GC61486 Neurokinin A TFA

    Substance K TFA; Neurokinin α TFA; Neuromedin L TFA

     Neurokinin A TFA is an endogenous tachykinin neuropeptide and a potent selective agonist of the neurokinin 2 receptor (NK2R). Neurokinin A TFA Chemical Structure
  36. GC36725 Neurokinin A(4-10) Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. Neurokinin A(4-10) Chemical Structure
  37. GC34683 Neurokinin A(4-10) TFA Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist. Neurokinin A(4-10) TFA Chemical Structure
  38. GC32020 Neurokinin antagonist 1

    Neurokinin antagonist 1 is a Neurokinin antagonist extracted from patent WO1998045262A1.

     Neurokinin antagonist 1 Chemical Structure
  39. GC11801 Neurokinin B (human, porcine) Neurokinin B (human, porcine) belongs to the tachykinin family of peptides. Neurokinin B (human, porcine) Chemical Structure
  40. GC34684 Neurokinin B TFA Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B TFA Chemical Structure
  41. GC30347 NK-1 Antagonist 1 NK-1 Antagonist 1 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression. NK-1 Antagonist 1 Chemical Structure
  42. GC69568 NK1 receptor antagonist 2

    NK1 receptor antagonist 2 is an NK1 receptor antagonist. It can be used for research on tinnitus and hearing loss.

     NK1 receptor antagonist 2 Chemical Structure
  43. GC36749 NKP608 NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. NKP608 Chemical Structure
  44. GC63131 Orvepitant maleate

    GW823296 maleate

     Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate Chemical Structure
  45. GC38829 Osanetant Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant Chemical Structure
  46. GC30861 Pavinetant (MLE-4901)

    AZD 2624, AZD 4901

     Pavinetant (MLE-4901) (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist. Pavinetant (MLE-4901) Chemical Structure
  47. GC31156 Physalaemin

    Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

     Physalaemin Chemical Structure
  48. GC15449 Rolapitant Orally active neurokinin NK1 receptor antagonist. Rolapitant Chemical Structure
  49. GC31143 Saredutant (SR 48968)

    SR 48968; SR 48968C

     Saredutant (SR 48968) is a selective (Neurokinin 2) NK2 receptor antagonist with an IC50 value of 0.13nM. Saredutant (SR 48968) Chemical Structure
  50. GC10107 SB-222200 An NK3 receptor antagonist SB-222200 Chemical Structure
  51. GC31198 Scyliorhinin II Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex. Scyliorhinin II Chemical Structure
  52. GC14839 Senktide NK3 tachykinin receptor agonist Senktide Chemical Structure
  53. GC33691 Serlopitant (VPD-737) Serlopitant (VPD-737) is a selective Neurokinin-1 (NK-1) receptor antagonist. Serlopitant (VPD-737) Chemical Structure
  54. GC69933 Spantide I TFA

    Spantide I TFA is an analogue of substance P and a selective antagonist of the neurokinin-1 receptor (NK1 receptor), with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptors, respectively. Spantide I can reduce type 1 cytokines in infected corneas and enhance type 2 cytokine IL-10, thereby significantly reducing corneal perforation.

     Spantide I TFA Chemical Structure
  55. GC37680 SSR-241586 SSR-241586 is an antagonist of neurokinin receptors. SSR-241586 Chemical Structure
  56. GC15649 Substance P Substance P, an important neuropeptide neurotransmitter, stimulates phosphatidylinositol turnover with an EC50 value of 0.36nM. Substance P Chemical Structure
  57. GC37695 Substance P (1-7)(TFA) Substance P (1-7)(TFA) Chemical Structure
  58. GC72212 Substance P (5-11) (TFA) Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (Substance P ), is a neuropeptide. Substance P (5-11) (TFA) Chemical Structure
  59. GC37696 Substance P 1-7 Substance P 1-7 is a fragment of the neuropeptide, substance P (SP). Substance P 1-7 Chemical Structure
  60. GC37697 Substance P 1-9 Substance P 1-9 is nonapeptide, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Substance P 1-9 Chemical Structure
  61. GC37698 Substance P 7-11 Substance P 7-11 is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration. Substance P 7-11 Chemical Structure
  62. GC39509 Substance P TFA

    Neurokinin P TFA

     Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. Substance P TFA Chemical Structure
  63. GC31221 Tachykinin angatonist 1 Tachykinin angatonist 1 is a neurokinin receptor antagonist extracted from patent US5968923, compound example 32. Tachykinin angatonist 1 Chemical Structure
  64. GC16026 Talnetant

    SB-223412

     A nonpeptide NK3 antagonist Talnetant Chemical Structure
  65. GC37730 Talnetant hydrochloride

    SB 223412 hydrochloride; SB 223412-A

     Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride Chemical Structure
  66. GC33735 Tradipitant (VLY-686)

    VLY-686; LY686017

     Tradipitant (VLY-686) (VLY-686) is a neurokinin-1 (NK-1) antagonist. Tradipitant (VLY-686) Chemical Structure
  67. GC33747 Vofopitant (GR 205171)

    GR 205171

     Vofopitant (GR 205171) is potent tachykinin NK1 receptor antagonist, with pKis of 10.6, 9.5, and 9.8 for human, rat and ferret NK1 receptor, respectively. Vofopitant (GR 205171) Chemical Structure
  68. GC37918 Vofopitant dihydrochloride

    GR 205171A

     Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent. Vofopitant dihydrochloride Chemical Structure
  69. GC30945 Y1 receptor antagonist 1

    H 409-22 isomer

    Y1 receptor antagonist 1 (H 409-22 isomer) is a neuropeptide Y1 receptor antagonist.

     Y1 receptor antagonist 1 Chemical Structure
  70. GC72766 Y1 receptor antagonist 1 formic

    H 409-22 isomer formic

     Y1 receptor antagonist 1 formic (H 409-22 isomer formic) is the formic salt form of Y1 receptor antagonist 1. Y1 receptor antagonist 1 formic Chemical Structure
  71. GC15122 [bAla8]-Neurokinin A(4-10)

    MEN 10210

     NK2 receptor agonist [bAla8]-Neurokinin A(4-10) Chemical Structure
  72. GC72115 [D-Pro2] Spantide I TFA [D-Pro2] Spantide I TFA is a Spantide analog. [D-Pro2] Spantide I TFA Chemical Structure
  73. GC35019 [Nle11]-Substance P [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems. [Nle11]-Substance P Chemical Structure
  74. GC13610 [Sar9,Met(O2)11]-Substance P

    NK1 tachykinin receptor agonist

     [Sar9,Met(O2)11]-Substance P Chemical Structure
  75. GC38013 [Sar9,Met(O2)11]-Substance P TFA [Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P TFA Chemical Structure
  76. GC35027 [Sar9] Substance P [Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist. [Sar9] Substance P Chemical Structure

75 Item(s)

per page

Set Descending Direction