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GSK467 Catalog No.GC34604

Size Price Stock Qty
10mM*1mL in DMSO
$218.00
In stock
5mg
$198.00
In stock
10mg
$288.00
In stock
50mg
$990.00
In stock
100mg
$1,755.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties

Cas No. 1628332-52-4 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C1C2=C(NC(OC3=CN(N=C3)CC4=CC=CC=C4)=N1)C=NC=C2
Formula C17H13N5O2 M.Wt 319.32
Solubility DMSO : 20.83 mg/mL (65.23 mM; Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

GSK467 is a selective KDM5 (JARID1) inhibitor with a ki of 10 nM for KDM5B, shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1]. ki: 10 nM (KDM5B)[1]

[1]. Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45.